Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963737 | 0.92 | OPRM1 (0.38) | PRMT5HTR7HTR1ANPC1RAB9A | |
| SCHEMBL8963679 | 0.90 | MEN1 (0.42) | PRMT5SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL8963580 | 0.89 | PRMT5 (0.40) | PRMT5SLC6A2SLC6A4TNKSPARP1 | |
| SCHEMBL8963561 | 0.89 | SLC6A2 (0.47) | HTR7SLC6A2SLC6A4HTR1ANPC1 | |
| Hydrochloric Acid SCHEMBL8963783 | 0.88 | PRMT5 (0.40) | PRMT5SLC6A2SLC6A4TNKSPARP1 | |
| SCHEMBL8963650 | 0.87 | CHEK2 (0.40) | PRMT5SLC6A2SLC6A4ALDH1A1TNKS | |
| Hydrochloric Acid SCHEMBL8963878 | 0.86 | PRMT5 (0.42) | PRMT5HTR7SLC6A2SLC6A4HTR1A | |
| SCHEMBL8963532 | 0.86 | SLC6A2 (0.41) | PRMT5HTR7SLC6A2SLC6A4HTR1A | |
| SCHEMBL8963467 | 0.85 | OPRD1 (0.41) | PRMT5SLC6A2SLC6A4TNKSTNKS2 | |
| SCHEMBL8963670 | 0.85 | PDE2A (0.42) | HTR7SLC6A2SLC6A4HTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |