Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963762 | 0.89 | HTR7 (0.44) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8964068 | 0.85 | PRMT5 (0.44) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8963561 | 0.85 | SLC6A2 (0.47) | SLC6A2SLC6A4CYP2D6HTR7HTR1A | |
| SCHEMBL8963552 | 0.81 | SLC6A4 (0.42) | SLC6A2SLC6A4CYP2D6HTR7HTR1A | |
| SCHEMBL8963679 | 0.79 | MEN1 (0.42) | SLC6A2SLC6A4DRD2DRD4DRD3 | |
| SCHEMBL8963956 | 0.79 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3CYP2D6HTR7 | |
| SCHEMBL8963532 | 0.78 | SLC6A2 (0.41) | SLC6A2SLC6A4CYP2D6HTR7HTR1A | |
| SCHEMBL8963737 | 0.77 | OPRM1 (0.38) | TLR9TLR7HTR7HTR1AHTR3A | |
| SCHEMBL8969991 | 0.77 | OPRD1 (0.37) | SLC6A2SLC6A4KCNH2CYP1A2TACR1 | |
| SCHEMBL8963580 | 0.77 | PRMT5 (0.40) | SLC6A2SLC6A4CYP1A2CYP3A4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |