Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963675 | 0.91 | TACR1 (0.36) | CHEK2TACR1PIN1OPRM1OPRD1 | |
| SCHEMBL8963516 | 0.88 | CHEK2 (0.42) | CHEK2CTSSOPRM1OPRD1NPY5R | |
| SCHEMBL8963580 | 0.87 | PRMT5 (0.40) | SLC6A4SLC6A2TACR1OPRD1CYP1A2 | |
| SCHEMBL8963787 | 0.87 | PIN1 (0.45) | SLC6A4SLC6A2TACR1PIN1NPY5R | |
| Hydrochloric Acid SCHEMBL8963783 | 0.86 | PRMT5 (0.40) | SLC6A4SLC6A2TACR1OPRD1CYP1A2 | |
| SCHEMBL8963532 | 0.86 | SLC6A2 (0.41) | SLC6A4SLC6A2TACR1PIN1OPRM1 | |
| SCHEMBL8963691 | 0.86 | TACR1 (0.34) | SLC6A4CHEK2TACR1OPRD1PRMT5 | |
| SCHEMBL8964088 | 0.86 | OPRD1 (0.37) | CHEK2OPRM1OPRD1ADRB1HTR1A | |
| SCHEMBL8963650 | 0.85 | CHEK2 (0.40) | SLC6A4SLC6A2CHEK2OPRD1NPY5R | |
| SCHEMBL8963679 | 0.82 | MEN1 (0.42) | SLC6A4SLC6A2PIN1OPRD1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |