Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968097 | 0.84 | SIGMAR1 (0.35) | SIGMAR1OPRM1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8968027 | 0.83 | TUBB3 (0.36) | SIGMAR1ALDH1A1TSHRFTOLMNA | |
| SCHEMBL8967635 | 0.81 | SLC6A4 (0.43) | SIGMAR1OPRM1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8967955 | 0.77 | SIGMAR1 (0.47) | SIGMAR1OPRM1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8967593 | 0.74 | ALDH1A1 (0.33) | SIGMAR1OPRM1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8967658 | 0.70 | SIGMAR1 (0.41) | SIGMAR1OPRM1KCNH2ALDH1A1TSHR | |
| SCHEMBL8967761 | 0.69 | SIGMAR1 (0.40) | SIGMAR1OPRM1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8967651 | 0.67 | SIGMAR1 (0.44) | SIGMAR1OPRM1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8554443 | 0.65 | CTSB (0.43) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL8967617 | 0.65 | TUBB3 (0.38) | SIGMAR1ALDH1A1FTOLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |