Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | HCN4 | Q9Y3Q4 | 4/20 | 0.35 |
| ▸ | HCN1 | O60741 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967617 | 0.83 | TUBB3 (0.38) | TUBB3HCN4HCN1TP53ALDH1A1 | |
| SCHEMBL8967505 | 0.83 | SIGMAR1 (0.35) | ALDH1A1SIGMAR1TSHRFTOLMNA | |
| SCHEMBL8967955 | 0.73 | SIGMAR1 (0.47) | HCN4HCN1SIGMAR1KDM4E | |
| SCHEMBL8967593 | 0.71 | ALDH1A1 (0.33) | ALDH1A1HSD17B10SIGMAR1TSHRSMN1; SMN2 | |
| SCHEMBL8967976 | 0.70 | HCN4 (0.42) | HCN4HCN1TP53ALDH1A1HSD17B10 | |
| SCHEMBL8967658 | 0.67 | SIGMAR1 (0.41) | TP53ALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL8967761 | 0.66 | SIGMAR1 (0.40) | HCN4HCN1SIGMAR1KDM4EFTO | |
| SCHEMBL8968081 | 0.66 | CHEK1 (0.46) | SIGMAR1KDM4E | |
| SCHEMBL8554443 | 0.64 | CTSB (0.43) | ALDH1A1SIGMAR1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL9162210 | 0.62 | IDO1 (0.50) | TUBB3ALDH1A1HSD17B10CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |