Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PER2 | O15055 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967593 | 0.90 | ALDH1A1 (0.33) | SIGMAR1ALDH1A1KDM4ETSHRSLC6A2 | |
| SCHEMBL8967505 | 0.84 | SIGMAR1 (0.35) | SIGMAR1ALDH1A1TSHRSLC6A3KCNH2 | |
| SCHEMBL8968120 | 0.80 | SLC6A3 (0.42) | SIGMAR1ALDH1A1KDM4ETSHRSLC6A2 | |
| SCHEMBL8968027 | 0.80 | TUBB3 (0.36) | SIGMAR1ALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL8967955 | 0.78 | SIGMAR1 (0.47) | SIGMAR1KDM4ESLC6A2SLC6A3KCNH2 | |
| SCHEMBL8967724 | 0.75 | SIGMAR1 (0.38) | SIGMAR1ALDH1A1KDM4ETSHRSLC6A2 | |
| SCHEMBL8967658 | 0.73 | SIGMAR1 (0.41) | SIGMAR1ALDH1A1KDM4ETSHRKCNH2 | |
| SCHEMBL5012208 | 0.71 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL5009898 | 0.71 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1KDM4ETSHRKMT2A | |
| SCHEMBL8967761 | 0.70 | SIGMAR1 (0.40) | SIGMAR1KDM4ESLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |