Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967955 | 0.81 | SIGMAR1 (0.47) | SIGMAR1OPRM1KCNH2RAB9ASLC6A2 | |
| SCHEMBL8967541 | 0.80 | SIGMAR1 (0.37) | SIGMAR1OPRM1KCNH2ALDH1A1MAPT | |
| SCHEMBL8968097 | 0.80 | SIGMAR1 (0.35) | SIGMAR1OPRM1KCNH2ALDH1A1MAPT | |
| SCHEMBL8967658 | 0.79 | SIGMAR1 (0.41) | SIGMAR1OPRM1KCNH2ALDH1A1RAB9A | |
| SCHEMBL8967505 | 0.76 | SIGMAR1 (0.35) | SIGMAR1OPRM1KCNH2ALDH1A1TSHR | |
| SCHEMBL8967761 | 0.73 | SIGMAR1 (0.40) | SIGMAR1OPRM1KCNH2RAB9AALKBH5 | |
| SCHEMBL8968027 | 0.72 | TUBB3 (0.36) | SIGMAR1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL8967593 | 0.70 | ALDH1A1 (0.33) | SIGMAR1OPRM1KCNH2ALDH1A1MAPT | |
| SCHEMBL14471536 | 0.63 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8967652 | 0.63 | SIGMAR1 (0.41) | SIGMAR1OPRM1KCNH2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |