Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29131534 | 0.96 | TDP1 (0.43) | TDP1MAPTATML3MBTL1LMNA | |
| SCHEMBL8986433 | 0.81 | TDP1 (0.66) | TDP1MAPTATML3MBTL1LMNA | |
| Picloram SCHEMBL29642909 | 0.81 | TDP1 (0.66) | TDP1MAPTATML3MBTL1LMNA | |
| Picloram SCHEMBL1888813 | 0.81 | TDP1 (0.66) | TDP1MAPTATML3MBTL1LMNA | |
| SCHEMBL11044076 | 0.78 | TDP1 (0.47) | TDP1MAPTATML3MBTL1LMNA | |
| SCHEMBL3569028 | 0.72 | MEN1 (0.37) | TDP1GAA | |
| SCHEMBL28448693 | 0.69 | TDP1 (0.32) | TDP1 | |
| Potassium Ion SCHEMBL10475426 | 0.68 | CA1 (0.32) | — | |
| SCHEMBL5941062 | 0.67 | TDP1 (0.33) | TDP1 | |
| SCHEMBL8409269 | 0.67 | TDP1 (0.33) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441457-B1 | Preparation of higher alkyl esters of carboxylic acids | DOWELANCO (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0441456-B1 | Removal of potassium chloride from solvents | DOWELANCO (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5214150-A | Preparation of higher alkylesters of carboxylic acids | DOWELANCO (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0441456-A2 | Removal of potassium chloride from solvents | DOWELANCO (US) | 1991-08-14 | — | — | EP | disclosed |
| EP-0441457-A2 | Preparation of higher alkyl esters of carboxylic acids | DOWELANCO (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4994252-A | Adding and removing water to increase particle size | DOWELANCO (US) | 1991-02-19 | — | — | US | disclosed |
| US-4976946-A | Solvent extraction by using N,N-dialkylamide or acetonitrile solvent | THE DOW CHEMICAL COMPANY (US) | 1990-12-11 | — | — | US | disclosed |