Sugi Predict

Sugi Predict / Compounds / SCHEMBL899018

SCHEMBL899018

SCHEMBL899018

COc1ccc(Cn2cc(O)c(C(C)=O)n2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AADAT Q8N5Z0 1/20 0.45
▸ KMT2A Q03164 3/20 0.44
▸ NPC1 O15118 3/20 0.44
▸ CACNA1G O43497 3/20 0.44
▸ CACNA1H O95180 3/20 0.44
▸ CACNA1I Q9P0X4 3/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ RAB9A P51151 2/20 0.44
▸ L3MBTL1 Q9Y468 2/20 0.43
▸ EGLN1 Q9GZT9 1/20 0.43
▸ HDAC1 Q13547 1/20 0.43
▸ CMA1 P23946 1/20 0.43
▸ PTGS2 P35354 1/20 0.43
▸ SNCA P37840 1/20 0.42
▸ HSP90AA1 P07900 1/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ GSK3A P49840 1/20 0.41
▸ GSK3B P49841 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ CYP19A1 P11511 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25411249 0.85 AADAT (0.42) AADATKMT2ANPC1CACNA1GCACNA1H
SCHEMBL369192 0.85 AADAT (0.44) AADATKMT2ANPC1CACNA1GCACNA1H
SCHEMBL6837473 0.84 AADAT (0.43) AADATKMT2ANPC1CACNA1GCACNA1H
SCHEMBL1144673 0.82 PARP1 (0.45) KMT2ANPC1CACNA1GCACNA1IMEN1
SCHEMBL17970934 0.78 GSK3A (0.44) KMT2AMEN1L3MBTL1PTGS2SMN1; SMN2
SCHEMBL15182512 0.78 UCHL1 (0.52) AADATKMT2ANPC1CACNA1GCACNA1H
SCHEMBL18864946 0.78 PTGS2 (0.55) KMT2AMEN1RAB9AHDAC1PTGS2
SCHEMBL18864949 0.78 PTGS2 (0.55) KMT2AMEN1RAB9AHDAC1PTGS2
SCHEMBL370448 0.78 L3MBTL1 (0.48) AADATKMT2ANPC1CACNA1GCACNA1H
SCHEMBL4100807 0.77 ALDH1A1 (0.49) AADATKMT2ANPC1CACNA1GCACNA1H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3888658-B1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS INC (US) 2023-12-27 — — EP disclosed
US-20230322777-A1 N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors PFIZER INC. (US) 2023-10-12 — — US disclosed
US-20230322777-A1 N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors PFIZER INC. (US) 2023-10-12 — — US disclosed
US-20230322777-A1 N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors PFIZER INC. (US) 2023-10-12 — — US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-11673890-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2023-06-13 — — US disclosed
US-11673890-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2023-06-13 — — US disclosed
US-11673890-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2023-06-13 — — US disclosed
US-20150008359-A1 REFRIGERANT COMPOSITION AND METHOD FOR SUPPRESSING DECOMPOSITION OF FLUOROHYDROCARBON IDEMITSU KOSAN CO., LTD (JP) 2015-01-08 — — US disclosed
US-8859577-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
US-8859577-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
US-8859577-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors PFIZER INC. (US) 2014-10-14 — — US disclosed
EP-2621493-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS Pfizer Inc (US) 2013-08-07 — — EP disclosed
US-20130190334-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2013-07-25 — — US disclosed
US-20130190334-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2013-07-25 — — US disclosed
US-20130190334-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2013-07-25 — — US disclosed
WO-2012042433-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2012-04-05 — — WO disclosed
WO-2012042433-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS PFIZER INC. (US) 2012-04-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190334-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS ACACA, ACACB, PC AADAT 680/4885KMT2A 2027/4885NPC1 258/4885
US-20230322777-A1 N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors ACACA, ACACB, PC AADAT 503/4885KMT2A 1514/4885NPC1 280/4885
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 AADAT 4641/4885KMT2A 1000/4885NPC1 3612/4885
US-11673890-B2 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors ACACA, ACACB, PC AADAT 517/4885KMT2A 1554/4885NPC1 267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.