Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | RGS4 | P49798 | 3/20 | 0.36 |
| ▸ | RGS8 | P57771 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899380 | 1.00 | MAPT (0.41) | MAPTSMN1; SMN2TP53TDP1PDE4D | |
| SCHEMBL899437 | 0.90 | PDE4D (0.39) | MAPTSMN1; SMN2TP53PDE4DPDE7A | |
| SCHEMBL899436 | 0.90 | PDE4D (0.39) | MAPTSMN1; SMN2TP53PDE4DPDE7A | |
| SCHEMBL899582 | 0.87 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2TP53PDE4DPDE7A | |
| SCHEMBL899584 | 0.87 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2TP53PDE4DPDE7A | |
| SCHEMBL899307 | 0.86 | MAPT (0.46) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL899306 | 0.86 | MAPT (0.46) | MAPTSMN1; SMN2TP53ALDH1A1LMNA | |
| SCHEMBL10045111 | 0.82 | PDE7A (0.36) | MAPTSMN1; SMN2TP53PDE4DPDE7A | |
| SCHEMBL903016 | 0.77 | ALDH1A1 (0.40) | MAPTSMN1; SMN2PTGS2ALDH1A1KDM4E | |
| SCHEMBL899463 | 0.77 | LMNA (0.43) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | claimed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |