Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000777 | 0.89 | KMT2A (0.37) | LMNAMEN1KMT2ATP53 | |
| SCHEMBL9000831 | 0.86 | TOP2A (0.37) | HTTMAPTRAB9ALMNASMN1; SMN2 | |
| SCHEMBL9000701 | 0.83 | EPHX1 (0.41) | MEN1KMT2A | |
| SCHEMBL9000768 | 0.83 | EPHX1 (0.41) | ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9000910 | 0.83 | SOAT1 (0.39) | RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9000610 | 0.82 | CTRC (0.39) | RAB9AMEN1KMT2A | |
| SCHEMBL9000671 | 0.80 | EPHX1 (0.34) | HTTMAPTRAB9ALMNAMEN1 | |
| SCHEMBL9000745 | 0.80 | EPHX1 (0.41) | HTTMAPTRAB9ALMNASMN1; SMN2 | |
| SCHEMBL9000839 | 0.79 | SOAT1 (0.38) | ALDH1A1HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL9000708 | 0.78 | EPHX1 (0.38) | ALDH1A1HTTMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |