Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000803 | 0.90 | SOAT1 (0.37) | SOAT1 | |
| SCHEMBL9000682 | 0.84 | SOAT1 (0.40) | SOAT1ALDH1A1NPSR1RAB9AKDM4E | |
| SCHEMBL9000515 | 0.84 | SOAT1 (0.36) | SOAT1KDM4EHPGD | |
| SCHEMBL9000583 | 0.80 | KDM1A (0.37) | SOAT1ALDH1A1KDM4EHPGD | |
| SCHEMBL9000550 | 0.74 | SORT1 (0.40) | SOAT1TSHR | |
| SCHEMBL32667998 | 0.73 | CYP1A2 (0.50) | SOAT1ALDH1A1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL9000766 | 0.73 | SOAT1 (0.38) | SOAT1HPGD | |
| SCHEMBL9000743 | 0.73 | SOAT1 (0.38) | SOAT1GAARAB9APOLBMAPT | |
| SCHEMBL9001013 | 0.71 | MAPT (0.42) | SOAT1ALDH1A1NPSR1KDM4EMAPT | |
| SCHEMBL9005392 | 0.71 | SOAT1 (0.41) | SOAT1NPC1ALDH1A1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |