Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.53 |
| ▸ | NOS3 | P29474 | 5/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901874 | 0.86 | ASIC3 (0.47) | NOS1NOS3CHRM2CHRM4ASIC3 | |
| SCHEMBL6618736 | 0.81 | NOS1 (0.64) | NOS1NOS3CHRM2CHRM4ASIC3 | |
| SCHEMBL4582523 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL6622090 | 0.78 | NOS1 (0.60) | NOS1NOS3CHRM2CHRM4ASIC3 | |
| SCHEMBL5338527 | 0.77 | OPRM1 (0.54) | — | |
| SCHEMBL23828889 | 0.77 | HCAR2 (0.55) | HIF1AMAPTTP53ALDH1A1KDM4E | |
| SCHEMBL902860 | 0.77 | MTNR1A (0.43) | NOS1NOS3CHRM2CHRM4ASIC3 | |
| SCHEMBL6623818 | 0.76 | NOS1 (0.66) | NOS1NOS3CHRM2CHRM4 | |
| SCHEMBL6620843 | 0.76 | SIGMAR1 (0.58) | NOS1NOS3ASIC3 | |
| SCHEMBL6620927 | 0.76 | NOS1 (0.60) | NOS1NOS3CHRM2CHRM4ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |