Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 4/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | USP28 | Q96RU2 | 4/20 | 0.42 |
| ▸ | USP25 | Q9UHP3 | 4/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902861 | 0.86 | NOS1 (0.53) | ASIC3NOS1NOS3KDM4ELMNA | |
| SCHEMBL901976 | 0.84 | ALDH1A1 (0.46) | KDM4ELMNACFDTP53HIF1A | |
| SCHEMBL903992 | 0.82 | NQO2 (0.46) | LARS1KDM4E | |
| SCHEMBL3345753 | 0.77 | FAAH (0.53) | CFD | |
| SCHEMBL21049906 | 0.76 | AKR1C3 (0.53) | — | |
| SCHEMBL1027287 | 0.75 | MAOA (0.56) | — | |
| SCHEMBL901406 | 0.75 | KARS1 (0.50) | ASIC3HRH4LARS1 | |
| SCHEMBL12469132 | 0.75 | KARS1 (0.72) | KDM4ELMNA | |
| SCHEMBL901872 | 0.75 | KARS1 (0.52) | HIF1A | |
| SCHEMBL902860 | 0.75 | MTNR1A (0.43) | ASIC3NOS1NOS3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |