Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027103 | 0.81 | ACHE (0.35) | NPC1RAB9ANPSR1TDP1L3MBTL1 | |
| SCHEMBL9026705 | 0.81 | SLC6A2 (0.37) | POLBNPC1RAB9ANPSR1TDP1 | |
| SCHEMBL9025568 | 0.76 | METAP2 (0.39) | POLBNPC1RAB9ANPSR1TDP1 | |
| SCHEMBL9025767 | 0.75 | SLC9A1 (0.37) | POLBNPC1RAB9ANPSR1TDP1 | |
| SCHEMBL9026972 | 0.74 | LPAR1 (0.35) | POLBNPC1RAB9ASLC6A2SLC6A4 | |
| SCHEMBL9025817 | 0.74 | LPAR1 (0.36) | POLBNPC1RAB9ANPSR1TDP1 | |
| SCHEMBL9024531 | 0.71 | HTT (0.35) | POLBRAB9ANPSR1SLC6A2SLC6A4 | |
| SCHEMBL9025682 | 0.71 | HTR2C (0.36) | POLBNPC1L3MBTL1 | |
| SCHEMBL9025107 | 0.69 | OPRK1 (0.35) | POLBNPC1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9025294 | 0.68 | HTT (0.33) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |