Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PAICS | P22234 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9030860 | 0.87 | KDM4E (0.39) | KDM4EL3MBTL1NEK2ALDH1A1LMNA | |
| SCHEMBL9025565 | 0.85 | MAPK14 (0.39) | KDM4EPAICSL3MBTL1KCNH2SCN9A | |
| SCHEMBL9061947 | 0.82 | S1PR1 (0.42) | ACP1 | |
| SCHEMBL9220071 | 0.81 | MEN1 (0.44) | — | |
| SCHEMBL9025502 | 0.80 | PDE7A (0.37) | PDE7APDE3APDE10AKDM4EPAICS | |
| SCHEMBL9025816 | 0.77 | KDM4E (0.35) | PDE7APDE3APDE10AKDM4EPAICS | |
| SCHEMBL9025514 | 0.75 | PDE4A (0.39) | KDM4EL3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL9026132 | 0.75 | HRH3 (0.49) | KDM4EKCNH2ALDH1A1MAPT | |
| SCHEMBL9032018 | 0.73 | DHFR (0.39) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL9026336 | 0.73 | CYP11B2 (0.47) | KDM4EALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |