Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032018 | 0.88 | DHFR (0.39) | CYP17A1TLR8TLR7NPC1RAB9A | |
| SCHEMBL9025454 | 0.82 | CA12 (0.34) | SMN1; SMN2MAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL9025514 | 0.82 | PDE4A (0.39) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9026325 | 0.79 | CYP11B2 (0.46) | CYP11B2CYP19A1CYP11B1MKNK1MKNK2 | |
| SCHEMBL9026859 | 0.79 | ADRA2A (0.45) | NPC1RAB9AMAPTKDM4EMAPK1 | |
| SCHEMBL9025089 | 0.79 | KDM4E (0.41) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9025520 | 0.79 | METAP2 (0.38) | MAPTKDM4EHSD17B10MEN1ALDH1A1 | |
| SCHEMBL9025565 | 0.78 | MAPK14 (0.39) | MAPTKDM4EMAPK1ABCB1ALDH1A1 | |
| SCHEMBL9024896 | 0.78 | MYB (0.36) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL9025568 | 0.78 | METAP2 (0.39) | NPC1RAB9AMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |