Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034191 | 0.79 | DRD2 (0.57) | HTR7HTR2ADRD2SLC6A4OPRM1 | |
| SCHEMBL9035549 | 0.79 | HTR1A (0.59) | HTR7HTR2ADRD2SLC6A4OPRM1 | |
| SCHEMBL9035121 | 0.78 | HTR7 (0.41) | TDP1HTR7HTR2ASLC6A4ADRA1D | |
| SCHEMBL8721112 | 0.69 | OPRM1 (0.48) | HTR7HTR2ADRD2SLC6A4OPRM1 | |
| SCHEMBL9032917 | 0.69 | SLC6A4 (0.65) | HTR7HTR2ADRD2SLC6A4HTR6 | |
| SCHEMBL9034780 | 0.69 | HTR1A (0.56) | HTR7HTR2ADRD2SLC6A4HTR6 | |
| SCHEMBL8723523 | 0.68 | HTR2C (0.54) | SLC6A4OPRM1OPRK1OPRL1HTR6 | |
| SCHEMBL9034110 | 0.67 | KDM4E (0.49) | HTR7HTR2ADRD2SLC6A4OPRM1 | |
| SCHEMBL9035807 | 0.67 | CYP1A2 (0.54) | HTR7HTR2ADRD2SLC6A4HTR6 | |
| SCHEMBL9034427 | 0.67 | OPRM1 (0.57) | TDP1HTR7HTR2ADRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |