Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035549 | 0.93 | HTR1A (0.59) | DRD2SLC6A4HTR1AOPRM1OPRL1 | |
| SCHEMBL9034357 | 0.88 | DRD2 (0.60) | DRD2SLC6A4HTR1AADRA1DOPRM1 | |
| SCHEMBL9035121 | 0.84 | HTR7 (0.41) | SLC6A4HTR1AADRA1DHTR7HTR2A | |
| SCHEMBL9033683 | 0.81 | SLC6A4 (0.64) | DRD2SLC6A4HTR1AOPRM1OPRL1 | |
| SCHEMBL9033100 | 0.79 | TDP1 (0.43) | DRD2SLC6A4HTR1AADRA1DOPRM1 | |
| SCHEMBL7260967 | 0.78 | ADRA1D (0.67) | DRD2SLC6A4HTR1AADRA1DADRA1B | |
| SCHEMBL9034110 | 0.77 | KDM4E (0.49) | DRD2SLC6A4HTR1AOPRM1OPRL1 | |
| SCHEMBL9034780 | 0.77 | HTR1A (0.56) | DRD2SLC6A4HTR1AHTR7HTR2A | |
| SCHEMBL9034948 | 0.77 | KCNH2 (0.52) | DRD2SLC6A4HTR1AADRA1DOPRM1 | |
| Hydrochloric Acid SCHEMBL7255426 | 0.77 | ADRA1D (0.68) | DRD2SLC6A4HTR1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |