Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1116045 | 0.98 | KDM4E (0.47) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL30129826 | 0.94 | KDM4E (0.44) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL3878826 | 0.94 | KDM4E (0.44) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL12942362 | 0.92 | KDM4E (0.43) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL9563079 | 0.92 | NTRK2 (0.44) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL12837837 | 0.91 | KDM4E (0.42) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL8380052 | 0.91 | KDM4E (0.44) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL13639964 | 0.90 | GAA (0.44) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL8074462 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL7592569 | 0.89 | KDM4E (0.43) | KDM4EALDH1A1HPGDPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368205-A1 | CHELATE COMPOUNDS | GE HEALTHCARE AS (NO) | 2024-11-07 | — | — | US | claimed |
| CN-116496171-A | Synthesis of iohexol | 上海慧聚药业有限公司 | 2023-07-28 | — | — | CN | claimed |
| EP-2289870-B1 | Method for purifying 5-amino-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide, an intermediate in the preparation of non-ionic X-ray contrast agents | GE HEALTHCARE AS (NO) | 2012-11-07 | — | — | EP | claimed |
| EP-2289870-A1 | Method for purifying 5-amino-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide, an intermediate in the preparation of non-ionic X-ray contrast agents | GE Healthcare AS (NO) | 2011-03-02 | — | — | EP | claimed |
| EP-2281803-A1 | Improvements in crystallization of 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6,-triiodo-isophthalamide, an intermediate for synthesizing non-ionic X-ray contrast agents | GE Healthcare AS (NO) | 2011-02-09 | — | — | EP | claimed |
| EP-2281804-A1 | A continuous process of preparing 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, an intermediate for synthesizing non-ionic X-ray contrast agents | GE Healthcare AS (NO) | 2011-02-09 | — | — | EP | claimed |
| US-20110021833-A1 | CRYSTALLIZATION OF AN INTERMEDIATE FOR SYNTHESIZING NON-IONIC X-RAY CONTRAST AGENTS | GE HEALTHCARE AS (NO) | 2011-01-27 | — | — | US | claimed |
| US-20110021834-A1 | CONTINUOUS PROCESS OF PREPARING INTERMEDIATE FOR NON-IONIC X-RAY CONTRAST AGENTS | GE HEALTHCARE AS (NO) | 2011-01-27 | — | — | US | claimed |
| US-20110021814-A1 | METHOD FOR REDUCING AMINOISOPHTHALIC ACID BISAMIDE RELATED IMPURITIES IN PREPARATION OF NON-IONIC X-RAY CONTRAST AGENTS | GE HEALTHCARE AS (NO) | 2011-01-27 | — | — | US | claimed |
| US-7863484-B1 | Eliminating the impurities of ABA monomethylester and of ABA dimer contained in an aqueous solution of 5-amino-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (ABA) or ABA hydrochloride by hydrolyzing them at a pH of 12-13 using sodium hydroxide; x-ray contrast agents, ioversol, iodixanol, iohexol | GE HEALTHCARE AS (NO) | 2011-01-04 | — | — | US | claimed |
| US-6441235-B1 | DI-LOWER-ALKYL-5-NITROISOPHTHALATE REACTS WITH A DIHYDROXY-MONOALKYLAMINE IN THE PRESENCE OF A BASIC CATALYST AND THEN CATALYLYTICALLY HYDROGENATED, WITHOUT ISOLATING THE 5-NITRO-N,N'-BIS(R)ISOPHTHALAMIDE INTERMEDIATE | AMERSHA, HEALTH AS (NO) | 2002-08-27 | — | — | US | claimed |
| EP-0984922-B1 | PREPARATION OF TRI-IODO BENZENE COMPOUNDS | NYCOMED IMAGING AS (NO) | 2002-08-07 | — | — | EP | claimed |
| US-20020095053-A1 | Preparation of 5-amino-isophthalamides | GE HEALTHCARE AS (NO) | 2002-07-18 | — | — | US | claimed |
| EP-0762900-B1 | IMPROVED SYNTHESIS OF IOVERSOL USING PHOSPHORIC ACID MODIFIED CO-ADDITION | MALLINCKRODT INC (US) | 2001-11-21 | — | — | EP | claimed |
| US-6274762-B1 | Preparation of tri-iodo benzene compounds | NYCOMED IMAGING AS (NO) | 2001-08-14 | — | — | US | claimed |
| US-6137006-A | IODINATING 2,4,6-UNSUBSTITUTED BENZENE RING CONTAINING COMPOUND WITH IODINE HALIDE IODINATING AGENT IN AQUEOUS REACTION MEDIUM, ADDING BASE, REDUCING AGENT AND AGITATING; ADDING SEED CRYSTALS; COOLING, PRECIPITATING REACTION PRODUCT | NYCOMED IMAGING AS (NO) | 2000-10-24 | — | — | US | claimed |
| EP-0484328-B1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS | MALLINCKRODT INC (US) | 1995-06-14 | — | — | EP | claimed |
| EP-0484328-A1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS. | MALLINCKRODT INC (US) | 1992-05-13 | — | — | EP | claimed |
| US-5013865-A | X-ray contrast media, controlled stoichiometry and kinetics | MALLINCKRODT, INC. (US) | 1991-05-07 | — | — | US | claimed |
| WO-1991001296-A1 | PROCESS FOR THE PREPARATION OF 2,4,6-TRIIODO-5-AMINO-N-ALKYLISOPHTHALAMIC ACID AND 2,4,6-TRIIODO-5-AMINO-ISOPHTHALAMIDE COMPOUNDS | MALLINCKRODT, INC. (US) | 1991-02-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021834-A1 | CONTINUOUS PROCESS OF PREPARING INTERMEDIATE FOR NON-IONIC X-RAY CONTRAST AGENTS | CNDP2, NISCH, PPIP5K2 | KDM4E 3330/4885ALDH1A1 4344/4885HPGD 2205/4885 |
| US-20240368205-A1 | CHELATE COMPOUNDS | SLC39A3, SLC39A11, MPI | KDM4E 902/4885ALDH1A1 3140/4885HPGD 2116/4885 |
| US-20110021814-A1 | METHOD FOR REDUCING AMINOISOPHTHALIC ACID BISAMIDE RELATED IMPURITIES IN PREPARATION OF NON-IONIC X-RAY CONTRAST AGENTS | PPIP5K2, AASDHPPT, ALAD | KDM4E 3662/4885ALDH1A1 4176/4885HPGD 2562/4885 |
| US-20110021833-A1 | CRYSTALLIZATION OF AN INTERMEDIATE FOR SYNTHESIZING NON-IONIC X-RAY CONTRAST AGENTS | IPO4, IPO5, REN | KDM4E 2220/4885ALDH1A1 3844/4885HPGD 4812/4885 |
| US-20020095053-A1 | Preparation of 5-amino-isophthalamides | DNPH1, DDAH1, DOHH | KDM4E 3057/4885ALDH1A1 892/4885HPGD 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.