Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10875431 | 0.96 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4131768 | 0.79 | ALDH1A1 (0.53) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL497367 | 0.79 | LMNA (0.60) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1272589 | 0.79 | LMNA (0.60) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1272587 | 0.79 | ALDH1A1 (0.53) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4184428 | 0.79 | HRH1 (0.57) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4063300 | 0.78 | HRH1 (0.55) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL477290 | 0.78 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| Potassium SCHEMBL4063307 | 0.78 | HRH1 (0.55) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11554269 | 0.77 | L3MBTL1 (0.46) | ALDH1A1NPC1RAB9AKMT2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35177-E | N-fluoropyridinium salt and process for preparing same | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0204535-B1 | N-FLUOROPYRIDINIUM SALT AND PROCESS FOR PREPARING SAME | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-5081249-A | From gaseous fluorine and solution of pyridinesulfonate | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-01-14 | — | — | US | disclosed |
| US-4996320-A | Thyroid inhibitors | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-02-26 | — | — | US | disclosed |
| EP-0204535-A1 | N-fluoropyridinium salt and process for preparing same | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1986-12-10 | — | — | EP | disclosed |