Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 10/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9088314 | 0.88 | RARA (0.39) | HTR6NAMPT | |
| SCHEMBL8797664 | 0.85 | HTR6 (0.37) | HTR6NAMPTPTGS2BACE1KCNH2 | |
| SCHEMBL8793951 | 0.84 | PTGS2 (0.39) | NAMPTPTGS2BACE1KCNH2 | |
| SCHEMBL9233065 | 0.83 | CYP11B1 (0.44) | NAMPTCYP2C9CYP2C19CYP1A2 | |
| SCHEMBL9087775 | 0.80 | ALDH1A1 (0.34) | HTR6NAMPTPTGS2BACE1CYP2C9 | |
| SCHEMBL9084957 | 0.79 | RAB9A (0.46) | PTGS2 | |
| SCHEMBL8196440 | 0.75 | CYP11B2 (0.46) | BACE1KCNH2LMNA | |
| SCHEMBL8796818 | 0.73 | KDM4E (0.33) | HTR6NAMPTPTGS2 | |
| SCHEMBL8794852 | 0.72 | CYP11B1 (0.43) | KCNH2 | |
| SCHEMBL8794632 | 0.72 | BACE1 (0.35) | BACE1KCNH2CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5493029-A | USEFUL IN TREATING ASTHMA AND HYPERTENSION | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1996-02-20 | — | — | US | disclosed |
| US-5300511-A | Spiro-benzopyran derivatives and useful for treating asthma and hypertension | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1994-04-05 | — | — | US | disclosed |
| EP-0514942-A1 | Novel benzopyran derivatives and processes for the preparation thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1992-11-25 | — | — | EP | disclosed |