Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL909573 | 0.84 | TDP1 (0.45) | ACMSD | |
| SCHEMBL123838 | 0.74 | TSHR (0.61) | PRKCIENPP2PRSS1PRSS2PRSS3 | |
| Potassium Ion SCHEMBL909654 | 0.73 | TSHR (0.42) | PRSS1PRSS2PRSS3TSHRNOS3 | |
| SCHEMBL4191589 | 0.72 | PRKCI (0.72) | PRKCIENPP2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL14334287 | 0.71 | ENPP2 (0.58) | PRKCIENPP2PRSS1PRSS2PRSS3 | |
| Potassium Ion SCHEMBL909968 | 0.71 | CYP3A4 (0.50) | ENPP2TSHR | |
| SCHEMBL18297788 | 0.70 | PRKCI (0.76) | PRKCIENPP2PRSS1PRSS2PRSS3 | |
| SCHEMBL23750141 | 0.69 | PRKCI (0.67) | PRKCIENPP2PRSS1PRSS2PRSS3 | |
| SCHEMBL3145457 | 0.69 | ENPP2 (0.50) | PRKCIENPP2PRSS1PRSS2PRSS3 | |
| SCHEMBL38187 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110004023-A1 | Potassium Organotrifluoroborate Derivative and a Production Method Therefor | SNU R & DB FOUNDATION (KR) | 2011-01-06 | — | — | US | claimed |
| US-8513465-B2 | Potassium organotrifluoroborate derivative and a production method therefor | SNU R&DB FOUNDATION (KR) | 2013-08-20 | — | — | US | disclosed |
| US-20110004023-A1 | Potassium Organotrifluoroborate Derivative and a Production Method Therefor | SNU R & DB FOUNDATION (KR) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110004023-A1 | Potassium Organotrifluoroborate Derivative and a Production Method Therefor | CYP4F11, KCNJ11, KCNA7 | PRKCI 2122/4885ENPP2 4457/4885PRSS1 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.