Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28998132 | 0.90 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPTMEN1LMNA | |
| SCHEMBL30410300 | 0.90 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPTMEN1LMNA | |
| SCHEMBL11909062 | 0.85 | MAPT (0.46) | ALDH1A1TDP1MAPTMEN1LMNA | |
| SCHEMBL11909063 | 0.85 | MAPT (0.46) | ALDH1A1TDP1MAPTMEN1LMNA | |
| SCHEMBL8549633 | 0.84 | LMNA (0.51) | ALDH1A1TDP1MAPTLMNAL3MBTL1 | |
| SCHEMBL11651148 | 0.83 | MMP2 (0.49) | ALDH1A1MAPTLMNAMC4RMAOB | |
| SCHEMBL8023603 | 0.83 | PPARA (0.44) | ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8485518 | 0.83 | LDHA (0.47) | — | |
| SCHEMBL4642323 | 0.82 | ALPI (0.49) | ALDH1A1TDP1LMNAL3MBTL1 | |
| SCHEMBL11208513 | 0.82 | ALDH1A1 (0.48) | ALDH1A1MEN1LMNAKMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426588-B2 | Phenylalanine derivatives | AJINOMOTO CO, INC. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-20120253041-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2012-10-04 | — | — | US | disclosed |
| US-8222405-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20110065918-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2011-03-17 | — | — | US | disclosed |
| EP-1288205-B1 | NOVEL PHENYLALANINE DERIVATIVES | AJINOMOTO KK (JP) | 2011-02-02 | — | — | EP | disclosed |
| US-7872125-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2011-01-18 | — | — | US | disclosed |
| EP-1477482-B1 | NOVEL PHENYLALANINE DERIVATIVE | AJINOMOTO KK (JP) | 2010-04-14 | — | — | EP | disclosed |
| US-7605165-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-7153963-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20060223836-A1 | New phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-10-05 | — | — | US | disclosed |
| US-20050101779-A1 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1477482-A1 | NOVEL PHENYLALANINE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2004-11-17 | — | — | EP | disclosed |
| US-20030220268-A1 | New phenylalanine derivatives | AJINOMOTO CO. INC (JP) | 2003-11-27 | — | — | US | disclosed |
| EP-1288205-A1 | NOVEL PHENYLALANINE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 2003-03-05 | — | — | EP | disclosed |
| EP-1157004-A1 | REGIOSELECTIVE SYNTHESIS OF DTPA DERIVATIVES | IDEC PHARMACEUTICALS CORPORATION (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051976-A1 | REGIOSELECTIVE SYNTHESIS OF DTPA DERIVATIVES | IDEC PHARMACEUTICALS CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223836-A1 | New phenylalanine derivatives | ITGB4, ITGA4, ITGAV | ALDH1A1 1310/4885TDP1 1862/4885MAPT 3090/4885 |
| US-20050101779-A1 | Phenylalanine derivatives | ITGB4, ITGA4, ITGB3 | ALDH1A1 987/4885TDP1 1683/4885MAPT 2070/4885 |
| US-20110065918-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, ITGA4, ITGAV | ALDH1A1 1310/4885TDP1 1862/4885MAPT 3090/4885 |
| US-20030220268-A1 | New phenylalanine derivatives | ITGB4, ITGA4, ITGB3 | ALDH1A1 1237/4885TDP1 1320/4885MAPT 3885/4885 |
| US-20120253041-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, ITGA4, ITGAV | ALDH1A1 1310/4885TDP1 1862/4885MAPT 3090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.