Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.46 |
| ▸ | BCL2 | P10415 | 3/20 | 0.41 |
| ▸ | BCL2L2 | Q92843 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105660 | 0.91 | BCL2 (0.42) | ALDH1A1ALDH2ALDH3A1BCL2BCL2L2 | |
| SCHEMBL9108726 | 0.88 | NPSR1 (0.42) | ALDH1A1ALDH2ALDH3A1SMN1; SMN2 | |
| SCHEMBL281661 | 0.86 | ALDH3A1 (0.48) | ALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL9108016 | 0.85 | ALDH1A1 (0.53) | ALDH1A1BCL2BCL2L2MCL1SMN1; SMN2 | |
| SCHEMBL9108120 | 0.84 | CUL4A (0.51) | ALDH1A1ALDH2ALDH3A1BCL2BCL2L2 | |
| SCHEMBL2480595 | 0.83 | ALDH3A1 (0.47) | ALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL21851967 | 0.83 | ALDH1A1 (0.50) | ALDH1A1BCL2BCL2L2SMN1; SMN2 | |
| SCHEMBL9109123 | 0.82 | BCL2 (0.49) | ALDH1A1BCL2BCL2L2MCL1 | |
| SCHEMBL9107616 | 0.82 | PARK7 (0.47) | ALDH1A1BCL2BCL2L2MCL1 | |
| SCHEMBL9103795 | 0.79 | FFAR2 (0.46) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | claimed |
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | KESTER ROBERT FRANCIS (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142705-A1 | ISATIN AND OXINDOLE COMPOUNDS | GPR119, INSR, OAT | ALDH1A1 646/4885ALDH2 138/4885ALDH3A1 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.