SCHEMBL9108679

SCHEMBL9108679

O=C(O)c1ccc(B(O)O)cc1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ASPH Q12797 1/20 0.46
CES2 O00748 2/20 0.46
MGLL Q99685 2/20 0.44
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
HPGD P15428 2/20 0.43
HSD17B10 Q99714 2/20 0.43
CFTR P13569 1/20 0.39
GRIK1 P39086 1/20 0.38
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
USP2 O75604 1/20 0.38
CYP2C19 P33261 1/20 0.38
CYP1A2 P05177 1/20 0.37
TAS2R14 Q9NYV8 2/20 0.36
NOTUM Q6P988 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29817020 1.00 ASPH (0.46) ASPHCES2MGLLKDM4EALDH1A1
SCHEMBL32678783 0.87 ASPH (0.49) ASPHCES2MGLLKDM4EALDH1A1
SCHEMBL32678781 0.87 ASPH (0.49) ASPHCES2MGLLKDM4EALDH1A1
SCHEMBL2555370 0.82 CFTR (0.49) CES2MGLLKDM4EALDH1A1HPGD
SCHEMBL29700447 0.78 MGLL (0.52) MGLLRXRARXRB
SCHEMBL918043 0.78 ALDH1A1 (0.44) MGLLKDM4EALDH1A1HSD17B10CYP2C19
SCHEMBL30807652 0.78 ALDH1A1 (0.44) MGLLKDM4EALDH1A1HSD17B10CYP2C19
SCHEMBL3789433 0.78 MGLL (0.52) MGLLRXRARXRB
SCHEMBL362047 0.77 CES2 (0.41) ASPHCES2KDM4EALDH1A1CYP1A2
SCHEMBL29689051 0.77 CES2 (0.41) ASPHCES2KDM4EALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250032533-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE GLYSCEND, INC. 2025-01-30 US disclosed
US-12059432-B2 Substituted phenyl boronic acid containing polymers and methods of use GLYSCEND, INC. (US) 2024-08-13 US disclosed
US-20240082297-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE GLYSCEND, INC. 2024-03-14 US disclosed
US-20230338415-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE GLYSCEND, INC. 2023-10-26 US disclosed
US-11576928-B2 Substituted phenyl boronic acid containing polymers and methods of use GLYSCEND, INC. (US) 2023-02-14 US disclosed
US-11491183-B2 Substituted phenyl boronic acid containing polymers and methods of use GLYSCEND, INC. (US) 2022-11-08 US disclosed
US-11491182-B2 Substituted phenyl boronic acid containing polymers and methods of use GLYSCEND, INC. (US) 2022-11-08 US disclosed
US-11484548-B2 Substituted phenyl boronic acid containing polymers and methods of use GLYSCEND, INC. (US) 2022-11-01 US disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-20220265703-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE GLYSCEND, INC. 2022-08-25 US disclosed
US-20160272617-A1 SUBSTITUTED PHENYLALANINE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-09-22 US disclosed
CN-105745192-A Substituted phenylalanine derivatives 拜耳制药股份公司 2016-07-06 CN disclosed
US-20150093291-A1 COMPETITIVE BINDING DENDRIMER-BASED SYSTEM FOR ANALYTE DETECTION RECEPTORS LLC (US) 2015-04-02 US disclosed
CN-103038245-B Modified c-3 betulinic acid derivatives as HIV maturation inhibitors BRISTOL MYERS SQUIBB CO 2015-03-25 CN disclosed
US-8754068-B2 Modified C-3 betulinic acid derivatives as HIV maturation inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-06-17 US disclosed
EP-2576585-A1 MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS Bristol-Myers Squibb Company (US) 2013-04-10 EP disclosed
CN-103038245-A Modified c-3 betulinic acid derivatives as HIV maturation inhibitors BRISTOL MYERS SQUIBB CO 2013-04-10 CN disclosed
WO-2013025616-A1 COMPETITIVE BINDING DENDRIMER-BASED SYSTEM FOR ANALYTE DETECTION RECEPTORS LLC (US) 2013-02-21 WO disclosed
US-20120142707-A1 MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-06-07 US disclosed
WO-2011153315-A1 MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11484548-B2 Substituted phenyl boronic acid containing polymers and methods of use SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-11491182-B2 Substituted phenyl boronic acid containing polymers and methods of use SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-20160272617-A1 SUBSTITUTED PHENYLALANINE DERIVATIVES PAH, PEPD, AADAT ASPH 129/4885CES2 1828/4885MGLL 2185/4885
US-20120142707-A1 MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS BET1, BIRC3, CYTH3 ASPH 2700/4885CES2 722/4885MGLL 2629/4885
US-20230338415-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-11576928-B2 Substituted phenyl boronic acid containing polymers and methods of use SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-11491183-B2 Substituted phenyl boronic acid containing polymers and methods of use SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-20250032533-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-20240082297-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-12059432-B2 Substituted phenyl boronic acid containing polymers and methods of use SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885
US-20220265703-A1 SUBSTITUTED PHENYL BORONIC ACID CONTAINING POLYMERS AND METHODS OF USE SLC10A2, PYGL, SLC10A1 ASPH 654/4885CES2 483/4885MGLL 1100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.