SCHEMBL911154

SCHEMBL911154

COc1cc([C]=O)ccc1O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.55
SLC22A6 Q4U2R8 1/20 0.53
SLC22A8 Q8TCC7 1/20 0.53
MEN1 O00255 1/20 0.53
RAB9A P51151 1/20 0.53
KMT2A Q03164 1/20 0.53
ALDH1A1 P00352 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
TRIM24 O15164 1/20 0.52
HPGD P15428 1/20 0.52
ALDH5A1 P51649 1/20 0.52
ABAT P80404 1/20 0.52
TRIM33 Q9UPN9 1/20 0.52
HTT P42858 1/20 0.52
TSHR P16473 3/20 0.47
NFKB1 P19838 2/20 0.47
GAA P10253 1/20 0.47
TRPA1 O75762 1/20 0.47
XDH P47989 1/20 0.46
BLM P54132 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL910063 0.84 ALDH1A1 (0.52) MEN1KMT2AALDH1A1TSHRNFKB1
SCHEMBL56335 0.81 CA2 (0.48) ALDH1A1TDP1HPGDTSHRGAA
SCHEMBL459931 0.80 MAOB (0.55) MAOBSLC22A6SLC22A8MEN1RAB9A
SCHEMBL15012969 0.80 MAOB (0.55) MAOBSLC22A6SLC22A8MEN1RAB9A
SCHEMBL29084199 0.80 MAOB (0.55) MAOBSLC22A6SLC22A8MEN1RAB9A
SCHEMBL5974207 0.80 MAOB (0.55) MAOBSLC22A6SLC22A8MEN1RAB9A
SCHEMBL29804271 0.80 MAOB (0.55) MAOBSLC22A6SLC22A8MEN1RAB9A
SCHEMBL6899032 0.79 ALDH1A1 (0.56) MEN1RAB9AKMT2AALDH1A1HPGD
SCHEMBL18130098 0.78 MAOB (0.64) MAOBSLC22A6SLC22A8MEN1RAB9A
SCHEMBL6302783 0.78 PTGS2 (0.50) MEN1KMT2AALDH1A1TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115784991-A N- (benzenesulfonyl) amide derivative and preparation method and application thereof 合肥医工医药股份有限公司 2023-03-14 CN claimed
US-20090324750-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF PSEUDOLYSIMACHION LONGIFOLIUM AND THE CATALPOL DERIVATIVES ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2009-12-31 US claimed
EP-1904054-A4 PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF PSEUDOLYSIMACHION LONGIFOLIUM AND THE CATALPOL DERIVATIVES ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY KOREA RES INST OF BIOSCIENCE (KR) 2008-12-31 EP claimed
JP-2008542363-A 2008-11-27 JP claimed
EP-1904054-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF PSEUDOLYSIMACHION LONGIFOLIUM AND THE CATALPOL DERIVATIVES ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY Korea Research Institute of Bioscience and Biotechnology (KR) 2008-04-02 EP claimed
WO-2006129964-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF PSEUDOLYSIMACHION LONGIFOLIUM AND THE CATALPOL DERIVATIVES ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2006-12-07 WO claimed
US-20050101541-A1 Lignan derivatives HORMOS MEDICAL CORPORATION (FI) 2005-05-12 US claimed
EP-1472206-A1 LIGNAN DERIVATIVES Hormos Medical Corporation (FI) 2004-11-03 EP claimed
EP-1171130-A4 PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME GUILFORD PHARM INC (US) 2004-05-19 EP claimed
WO-2003066556-A1 LIGNAN DERIVATIVES HORMOS MEDICAL CORPORATION (FI) 2003-08-14 WO claimed
US-20030078212-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME GUILFORD PHARMACEUTICALS INC. 2003-04-24 US claimed
JP-2002540060-A 2002-11-26 JP claimed
EP-1171130-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME GUILFORD PHARMACEUTICALS INC. (US) 2002-01-16 EP claimed
WO-2000025787-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME GUILFORD PHARMACEUTICALS INC. (US) 2000-05-11 WO claimed
JP-2180846-A None JP disclosed
JP-4275296-A None JP disclosed
CN-115784991-A N- (benzenesulfonyl) amide derivative and preparation method and application thereof 合肥医工医药股份有限公司 2023-03-14 CN disclosed
US-4785010-A AGING RESISTANCE OF HUMANS CASSELLA AKTIENGESELLSCHAFT (DE) 1988-11-15 US disclosed
EP-0124067-B1 2-(AMINOALKYL)-PYRROLE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE CASSELLA Aktiengesellschaft (DE) 1986-12-17 EP disclosed
EP-0124067-A1 2-(Aminoalkyl)-pyrrole derivatives, process for their manufacture and their use CASSELLA Aktiengesellschaft (DE) 1984-11-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090324750-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF PSEUDOLYSIMACHION LONGIFOLIUM AND THE CATALPOL DERIVATIVES ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY IL4, IL5, MMP13 MAOB 3325/4885SLC22A6 2474/4885SLC22A8 4018/4885
US-20050101541-A1 Lignan derivatives EBP, ELOVL3, LCT MAOB 2671/4885SLC22A6 880/4885SLC22A8 684/4885
US-20030078212-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME PARP10, PARG, DERA MAOB 2436/4885SLC22A6 1309/4885SLC22A8 3667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.