Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123046 | 0.82 | MGLL (0.40) | MEN1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL9550629 | 0.77 | MGLL (0.58) | MEN1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL9622079 | 0.68 | LMNA (0.52) | MEN1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL17534193 | 0.66 | CHRNB2 (0.53) | MEN1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL3315840 | 0.64 | KMT2A (0.62) | KMT2A | |
| SCHEMBL8012997 | 0.64 | MAOA (0.54) | MEN1KMT2AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL30361079 | 0.64 | KMT2A (0.62) | KMT2A | |
| SCHEMBL1486040 | 0.64 | GPR174 (0.62) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1092175 | 0.63 | MAOB (0.60) | MEN1KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2552245 | 0.63 | ENPP2 (0.56) | MEN1KMT2AMAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420155-A | Treatment of nervous system disorders with derivatives of 4-hydroxy-2-(1H)-pyrrolones such as strokes, antiischemic agents or cardiovascular disorders | MERCK SHARP & DOHME LTD. (GB) | 1995-05-30 | — | — | US | disclosed |