Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28285675 | 0.78 | ALDH1A1 (0.51) | POLBALDH1A1HTR1DGABRA1GABRB2 | |
| SCHEMBL7608 | 0.78 | CA1 (0.52) | POLBALDH1A1CA1CA2MMP1 | |
| SCHEMBL10750846 | 0.77 | POLB (0.43) | POLBALDH1A1CA1CA2HTR1D | |
| SCHEMBL5360634 | 0.77 | CA1 (0.34) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL11139384 | 0.76 | RAPGEF4 (0.39) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL3609619 | 0.76 | GAA (0.40) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL27461978 | 0.76 | NR1I2 (0.47) | POLBALDH1A1CA1CA2HTR1D | |
| SCHEMBL9521335 | 0.74 | L3MBTL1 (0.42) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL28784149 | 0.74 | RXRA (0.42) | POLBALDH1A1CA1CA2HTR1D | |
| SCHEMBL3440241 | 0.74 | CA1 (0.37) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713293-B2 | Substituted biaryl sulfonamides and the use thereof | NOVOMEDIX, LLC (US) | 2023-08-01 | — | — | US | disclosed |
| US-20220002240-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | NOVOMEDIX LLC (US) | 2022-01-06 | — | — | US | disclosed |
| US-20200062700-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | NOVOMEDIX LLC (US) | 2020-02-27 | — | — | US | disclosed |
| CN-109574881-A | A kind of preparation method of symmetrical diaryldisulfide | 沾化大荣化工科技有限公司 | 2019-04-05 | — | — | CN | disclosed |
| US-20180327353-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | NOVOMEDIX LLC (US) | 2018-11-15 | — | — | US | disclosed |
| US-10040757-B2 | Substituted biaryl sulfonamides and the use thereof | NOVOMEDIX, LLC (US) | 2018-08-07 | — | — | US | disclosed |
| EP-2925718-B1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | NOVOMEDIX LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| US-20170158627-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | NOVOMEDIX, LLC | 2017-06-08 | — | — | US | disclosed |
| US-9604924-B2 | Substituted biaryl sulfonamides and the use thereof | NOVOMEDIX, LLC (US) | 2017-03-28 | — | — | US | disclosed |
| US-9365471-B2 | Substituted phenylsulfur trifluoride and other like fluorinating agents | UBE INDUSTRIES, LTD. (JP) | 2016-06-14 | — | — | US | disclosed |
| US-7381846-B2 | E.g., Bis(2,6-dimethyl-3-chloro-4-tert-butylphenyl)disulfide and Bis(2,6-dimethyl-3,5-dichloro-4-tert-butylphenyl)disulfide; high yields; can be handled and stored in a safe manner; cost effective | IM&T RESEARCH, INC. (US) | 2008-06-03 | — | — | US | disclosed |
| US-20080039660-A1 | E.g., Bis(2,6-dimethyl-3-chloro-4-tert-butylphenyl)disulfide and Bis(2,6-dimethyl-3,5-dichloro-4-tert-butylphenyl)disulfide; high yields; can be handled and stored in a safe manner; cost effective | IM&T RESEARCH, INC. (US) | 2008-02-14 | — | — | US | disclosed |
| US-20080039660-A1 | E.g., Bis(2,6-dimethyl-3-chloro-4-tert-butylphenyl)disulfide and Bis(2,6-dimethyl-3,5-dichloro-4-tert-butylphenyl)disulfide; high yields; can be handled and stored in a safe manner; cost effective | IM&T RESEARCH, INC. (US) | 2008-02-14 | — | — | US | disclosed |
| WO-2008014345-A2 | SUBSTITUTED PHENYLSULFUR TRIFLUORIDE AND OTHER LIKE FLUORINATING AGENTS | IM & T RESEARCH, INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| US-7265247-B1 | E.g., 2,6-dimethyl-4-tert-butylphenylsulfur trifluoride and 4-chlorophenylsulfur trifluoride; especially for fluorinating target compounds that have one or more oxygen or oxygen-containing groups that are replaced by the introduction of one or more fluorine atoms. | IM&T RESEARCH, INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265247-B1 | E.g., 2,6-dimethyl-4-tert-butylphenylsulfur trifluoride and 4-chlorophenylsulfur trifluoride; especially for fluorinating target compounds that have one or more oxygen or oxygen-containing groups that are replaced by the introduction of one or more fluorine atoms. | IM&T RESEARCH, INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265247-B1 | E.g., 2,6-dimethyl-4-tert-butylphenylsulfur trifluoride and 4-chlorophenylsulfur trifluoride; especially for fluorinating target compounds that have one or more oxygen or oxygen-containing groups that are replaced by the introduction of one or more fluorine atoms. | IM&T RESEARCH, INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| US-4218476-A | Anti-thrombotic N-alkylthioakylamino benzenesulfonamides | AB KABI (SE) | 1980-08-19 | — | — | US | disclosed |
| EP-0000826-A1 | Diorthosubstituted benzene derivatives, especially for use in a method of therapy, processes for their preparation, and pharmaceutical compositions containing them | Kabi AB (SE) | 1979-02-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180327353-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | EIF2AK2, TP53, KRAS | POLB 986/4885ALDH1A1 2107/4885CA1 2889/4885 |
| US-11713293-B2 | Substituted biaryl sulfonamides and the use thereof | EIF2AK2, TP53, KRAS | POLB 986/4885ALDH1A1 2107/4885CA1 2889/4885 |
| US-20220002240-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | EIF2AK2, TP53, KRAS | POLB 873/4885ALDH1A1 2041/4885CA1 2941/4885 |
| US-20170158627-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | EIF2AK2, TP53, KRAS | POLB 986/4885ALDH1A1 2107/4885CA1 2889/4885 |
| US-20200062700-A1 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF | EIF2AK2, TP53, KRAS | POLB 986/4885ALDH1A1 2107/4885CA1 2889/4885 |
| US-10040757-B2 | Substituted biaryl sulfonamides and the use thereof | EIF2AK2, TP53, KRAS | POLB 986/4885ALDH1A1 2107/4885CA1 2889/4885 |
| US-20080039660-A1 | E.g., Bis(2,6-dimethyl-3-chloro-4-tert-butylphenyl)disulfide and Bis(2,6-dimethyl-3,5-dichloro-4-tert-butylphenyl)disulfide; high yields; can be handled and stored in a safe manner; cost effective | TST, DDT, ESD | POLB 2700/4885ALDH1A1 2815/4885CA1 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.