SCHEMBL9176348

SCHEMBL9176348

O=C(Br)Oc1cc(C(=O)Cl)cc(C(=O)Cl)c1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.32
TSHR P16473 1/20 0.32
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9181289 0.82 MEN1 (0.32) MEN1KMT2A
SCHEMBL890486 0.82 POLB (0.31) ALDH1A1TSHR
SCHEMBL195019 0.78 LMNA (0.43) ALDH1A1MEN1KMT2A
SCHEMBL11699992 0.77 MEN1 (0.32) ALDH1A1TSHRMEN1KMT2A
SCHEMBL38576 0.75 ALDH1A1 (0.40) ALDH1A1TSHR
SCHEMBL11702300 0.75 TPMT (0.40) ALDH1A1TSHRMEN1KMT2A
SCHEMBL392901 0.74 LMNA (0.47) MEN1KMT2A
SCHEMBL3361585 0.73 CES2 (0.47) ALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL18918955 0.72 ALDH1A1 (0.39) ALDH1A1TSHR
SCHEMBL809410 0.72 ELANE (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0473459-B1 Reverse osmosis membranes of polyamideurethane DU PONT (US) 1995-07-26 EP disclosed
US-5137606-A Forming chloroformyloxy-substituted isophthaloyl chloride; reacting hydroxy-substituted isophthalic acid, catlayst, phosgene, solvent E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-11 US disclosed
EP-0473459-A2 Reverse osmosis membranes of polyamideurethane E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-03-04 EP disclosed
US-5085777-A Improved solute rejection and permeation properties E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-02-04 US disclosed