SCHEMBL918686

SCHEMBL918686

O=P(Cl)(Cl)c1ccc(Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
CYP2A6 P11509 1/20 0.47
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 2/20 0.38
MAPK1 P28482 2/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
ENPP2 Q13822 1/20 0.38
CYP3A4 P08684 1/20 0.38
HSD17B10 Q99714 1/20 0.38
MMP2 P08253 1/20 0.37
MMP8 P22894 1/20 0.37
MMP14 P50281 1/20 0.37
IDO1 P14902 1/20 0.36
TSHR P16473 2/20 0.36
ALOX15 P16050 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11808065 0.90 CES2 (0.42) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL12353492 0.87 HPGD (0.36) LMNATSHRCA2CA4CA5A
SCHEMBL5676701 0.86 MAOA (0.50) LMNAMEN1KMT2AALDH1A1CYP3A4
SCHEMBL10340793 0.82 LMNA (0.47) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL1000520 0.79 LMNA (0.50) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL11144244 0.78 LMNA (0.42) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL25146402 0.74 LMNA (0.44) LMNACYP2A6MEN1KMT2AALDH1A1
Potassium Ion SCHEMBL6228946 0.74 LMNA (0.44) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL11795326 0.74 LMNA (0.44) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL10425734 0.74 MEN1 (0.50) LMNACYP2A6MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119119635-A Ageing-resistant material prepared from recycled polypropylene and preparation method thereof 肇庆市合亚科技有限公司 2024-12-13 CN claimed
CN-119119635-A Ageing-resistant material prepared from recycled polypropylene and preparation method thereof 肇庆市合亚科技有限公司 2024-12-13 CN disclosed
CN-107148423-B Thionucleoside derivative or salt thereof and pharmaceutical composition 富士胶片株式会社 2021-07-30 CN disclosed
EP-3102215-B1 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION RIBOSCIENCE LLC (US) 2021-06-16 EP disclosed
EP-3214090-B1 THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FUJIFILM CORP (JP) 2020-08-19 EP disclosed
US-10385089-B2 Thionucleoside derivative or salt thereof, and pharmaceutical composition FUJIFILM CORPORATION (JP) 2019-08-20 US disclosed
US-20180319834-A1 THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FUJIFILM CORPORATION (JP) 2018-11-08 US disclosed
US-10092649-B2 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication RIBOSCIENCE LLC (US) 2018-10-09 US disclosed
US-10059734-B2 Thionucleoside derivative or salt thereof, and pharmaceutical composition FUJIFILM CORPORATION (JP) 2018-08-28 US disclosed
US-20170296664-A1 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication RIBOSCIENCE LLC 2017-10-19 US disclosed
US-4656293-A Process for preparing organic chlorophosphanes HOECHST AKTIENGESELLSCHAFT (DE) 1987-04-07 US disclosed
US-4632995-A Process for the preparation of phenyl- and thienyl-chlorophosphane derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1986-12-30 US disclosed
EP-0144743-A1 Process for the preparation of organic chlorophosphanes HOECHST AKTIENGESELLSCHAFT (DE) 1985-06-19 EP disclosed
EP-0122587-A2 Process for preparing organic chlorophosphanes HOECHST AKTIENGESELLSCHAFT (DE) 1984-10-24 EP disclosed
US-4319913-A Substituted benzazaphospholes, herbicidal compositions and the use thereof MONSANTO COMPANY (US) 1982-03-16 US disclosed
US-RE30279-E FROM ALKYL OR ARYL HALIDE WITH HALO-SUBSTITUTED TRIVALENT PHOSPHORUS COMPOUNDS AND PHOSPHORUS PENTASULFIDE OR -OXIDE STAUFFER CHEMICAL COMPANY (US) 1980-05-20 US disclosed
US-4046884-A N-(α-Aminoalkylidene)phosphor- and phosphonamidates, and method for controlling insects VELSICOL CHEMICAL CORPORATION (US) 1977-09-06 US disclosed
US-4000239-A PROCESS FOR SPINNING NAPHTHALATE POLYESTER FIBERS TEIJIN LIMITED (JA) 1976-12-28 US disclosed
US-3965220-A AMINE CATALYST MONSANTO COMPANY (US) 1976-06-22 US disclosed
US-3950413-A Process for the preparation of phosphonic acid dihalides HOECHST AKTIENGESELLSCHAFT (DT) 1976-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180319834-A1 THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION SLC11A2, RNASE1, KRAS LMNA 4093/4885CYP2A6 4108/4885MEN1 2626/4885
US-10385089-B2 Thionucleoside derivative or salt thereof, and pharmaceutical composition SLC11A2, RNASE1, KRAS LMNA 4093/4885CYP2A6 4108/4885MEN1 2626/4885
US-10059734-B2 Thionucleoside derivative or salt thereof, and pharmaceutical composition SLC11A2, RNASE1, TYMP LMNA 4144/4885CYP2A6 4094/4885MEN1 2253/4885
US-10092649-B2 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication RNMT, RNGTT, DUT LMNA 2116/4885CYP2A6 2716/4885MEN1 4580/4885
US-20170296664-A1 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication RNMT, DUT, RNGTT LMNA 2212/4885CYP2A6 2688/4885MEN1 4578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.