Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9188603 | 0.91 | ALDH1A1 (0.56) | ALDH1A1HPGDPTGS2TSHRCYP2C9 | |
| SCHEMBL9183908 | 0.83 | L3MBTL1 (0.48) | ALDH1A1HPGDPTGS2TSHR | |
| SCHEMBL9185538 | 0.78 | L3MBTL1 (0.50) | ALDH1A1HPGDPTGS2TSHRCYP3A4 | |
| SCHEMBL9187134 | 0.73 | PTGS2 (0.56) | ALDH1A1HPGDPTGS2TSHRCYP3A4 | |
| SCHEMBL9184179 | 0.73 | L3MBTL1 (0.52) | ALDH1A1HPGDTSHRCYP2C9CYP2C19 | |
| SCHEMBL9190464 | 0.72 | GAA (0.46) | ALDH1A1PTGS2TSHRCYP3A4CYP2C9 | |
| SCHEMBL9867799 | 0.68 | HTR1A (0.51) | ALDH1A1HPGD | |
| SCHEMBL7542346 | 0.68 | ALDH1A1 (0.54) | ALDH1A1HPGDTSHRCYP3A4GAA | |
| Oxalic Acid SCHEMBL9868595 | 0.67 | HTR1A (0.49) | ALDH1A1HPGDTSHRGAAKDM4E | |
| SCHEMBL10913065 | 0.66 | MAPT (0.59) | ALDH1A1CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576475-B1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO SPA (IT) | 1995-09-20 | — | — | EP | disclosed |
| US-5376673-A | Vasodilation | ITALFARMACO S.P.A. (IT) | 1994-12-27 | — | — | US | disclosed |
| EP-0576475-A1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY. | ITALFARMACO SPA (IT) | 1994-01-05 | — | — | EP | disclosed |
| WO-1992016506-A1 | ISOINDOLES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1992-10-01 | — | — | WO | disclosed |