SCHEMBL920221

SCHEMBL920221

Nc1ncccc1C(=O)NCc1ccc(Oc2ccc(I)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.55
HPGD P15428 3/20 0.51
LMNA P02545 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
EGLN1 Q9GZT9 1/20 0.47
KMT2A Q03164 2/20 0.46
POLB P06746 1/20 0.46
MEN1 O00255 1/20 0.46
MAPT P10636 1/20 0.46
CYP3A4 P08684 1/20 0.45
HTT P42858 1/20 0.45
MMP13 P45452 1/20 0.45
MAPK14 Q16539 1/20 0.45
NSD2 O96028 1/20 0.45
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920461 0.90 MAPK8 (0.67) MAPK8HPGDLMNASMN1; SMN2KMT2A
SCHEMBL920462 0.90 MAPK8 (0.53) MAPK8HPGDLMNASMN1; SMN2KMT2A
SCHEMBL920985 0.90 MAPK8 (0.53) MAPK8HPGDKMT2APOLBMEN1
SCHEMBL921037 0.88 HPGD (0.66) MAPK8HPGDLMNASMN1; SMN2EGLN1
SCHEMBL920473 0.88 HPGD (0.57) MAPK8HPGDLMNASMN1; SMN2EGLN1
SCHEMBL920265 0.88 MAPK8 (0.55) MAPK8HPGDLMNASMN1; SMN2EGLN1
SCHEMBL922025 0.88 ALDH1A1 (0.58) MAPK8HPGDLMNASMN1; SMN2EGLN1
SCHEMBL920343 0.88 KMT2A (0.61) MAPK8HPGDLMNASMN1; SMN2KMT2A
SCHEMBL922484 0.88 HPGD (0.62) MAPK8HPGDLMNASMN1; SMN2EGLN1
SCHEMBL920793 0.87 LMNA (0.61) MAPK8HPGDLMNASMN1; SMN2EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885HPGD 1273/4885LMNA 4812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.