Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | HTR2C | P28335 | 5/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685616 | 0.87 | HTR1A (0.60) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL9685648 | 0.85 | CMA1 (0.56) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL9686038 | 0.85 | ALDH1A1 (0.51) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL9685728 | 0.81 | PDE3B (0.69) | HTR1AHTR2CPDE3BPDE3AMAPT | |
| SCHEMBL9685633 | 0.81 | KIF11 (0.51) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL9686113 | 0.81 | PGR (0.50) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL11538972 | 0.80 | FEN1 (0.42) | HTR1AHTR2CFEN1HPGD | |
| SCHEMBL9684898 | 0.78 | HTR1A (0.43) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL9204486 | 0.77 | MAPT (0.59) | HTR1AHTR2CPDE3BPDE3APGR | |
| SCHEMBL7765507 | 0.77 | PDE3B (0.50) | HTR1AHTR2CPDE3BPDE3APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430800-B1 | Substituted benzothiazolinones, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-01-25 | — | — | EP | claimed |
| US-5084469-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1992-01-28 | — | — | US | claimed |
| JP-3176480-A | — | — | None | — | — | JP | disclosed |
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| EP-0650485-A1 | 2,5-DIARYL TETRAHYDRO-THIOPHENES, -FURANS AND ANALOGS FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED, INC. (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |
| US-5084469-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1992-01-28 | — | — | US | disclosed |
| JP-H03176480-A | NEW SUBSTITUTED BENZOTHIAZOLINONES, THEIR PRODUCTION AND MEDICINAL COMPOSITIONS CONTAINING THEM | ADIR | 1991-07-31 | — | — | JP | disclosed |