Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921471 | 0.80 | ALDH1A1 (0.49) | LTA4HALDH1A1HPGDSMN1; SMN2TSHR | |
| SCHEMBL7999310 | 0.78 | MAOA (0.46) | LTA4HALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL995326 | 0.78 | LTA4H (0.55) | LTA4HALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL26259923 | 0.77 | NPC1 (0.42) | LTA4HALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL26259521 | 0.75 | ACHE (0.41) | LTA4HALOX5PTGS1PTGS2ALDH1A1 | |
| Hydrogen Sulfide SCHEMBL752785 | 0.75 | LTA4H (0.53) | LTA4HALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL1194484 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27961856 | 0.74 | LTA4H (0.42) | LTA4HALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL26259657 | 0.74 | ACHE (0.37) | LTA4HALOX5PTGS1PTGS2ALDH1A1 | |
| Phosphine SCHEMBL2238711 | 0.73 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127642-A1 | SELECTIVE VALORIZATION OF BIOMASS SUGARS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-06-24 | — | — | WO | claimed |
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-11618763-B2 | Selective valorization of biomass sugars | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-04-04 | — | — | US | disclosed |
| US-11584714-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210188890-A1 | SELECTIVE VALORIZATION OF BIOMASS SUGARS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2021-06-24 | — | — | US | disclosed |
| WO-2021127642-A1 | SELECTIVE VALORIZATION OF BIOMASS SUGARS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-06-24 | — | — | WO | disclosed |
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
| US-8034811-B2 | Hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2011-10-11 | — | — | US | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| EP-0462812-B1 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | disclosed |
| EP-0409413-B1 | Diaryl ether heterocycles | ICI PLC (GB) | 1994-08-03 | — | — | EP | disclosed |
| EP-0409412-B1 | Diaryl ether cyclic ethers | ICI PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| EP-0462812-A2 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |
| EP-0409413-A2 | Diaryl ether heterocycles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
| EP-0409412-A2 | Diaryl ether cyclic ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584714-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | LTA4H 3392/4885ALOX5 3613/4885PTGS1 3961/4885 |
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | BACE1, STS, APP | LTA4H 1308/4885ALOX5 3052/4885PTGS1 2472/4885 |
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | MASP2, METAP2, SPINT2 | LTA4H 3392/4885ALOX5 3613/4885PTGS1 3961/4885 |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | LTA4H 2778/4885ALOX5 3023/4885PTGS1 1276/4885 |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | LTA4H 2778/4885ALOX5 3023/4885PTGS1 1276/4885 |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | LTA4H 2778/4885ALOX5 3023/4885PTGS1 1276/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | LTA4H 2778/4885ALOX5 3023/4885PTGS1 1276/4885 |
| US-11618763-B2 | Selective valorization of biomass sugars | GALE, FBP1, GNE | LTA4H 1208/4885ALOX5 2128/4885PTGS1 3711/4885 |
| US-20210188890-A1 | SELECTIVE VALORIZATION OF BIOMASS SUGARS | GALE, FBP1, GNE | LTA4H 1208/4885ALOX5 2128/4885PTGS1 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.