Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HK1 | P19367 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GALK1 | P51570 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38765 | 0.75 | BRPF1 (0.39) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL8800787 | 0.67 | HSD17B10 (0.44) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL8991819 | 0.67 | LMNA (0.36) | ALOX15HSD17B10GAAKDM4EMEN1 | |
| SCHEMBL1236095 | 0.67 | LMNA (0.36) | ALOX15HSD17B10GAAKDM4EMEN1 | |
| SCHEMBL24289878 | 0.67 | ALOX15 (0.36) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL8317265 | 0.67 | ALOX15 (0.36) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL31116493 | 0.67 | ALOX15 (0.50) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL14865384 | 0.67 | RAB9A (0.38) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL4111485 | 0.67 | NOS2 (0.44) | ALOX15HSD17B10GAANPSR1KDM4E | |
| SCHEMBL28284830 | 0.67 | ALOX15 (0.36) | ALOX15HSD17B10GAANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466452-B1 | Thioxo heterocycles and their pharmaceutical use | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5240941-A | Enzyme inhibitors; antiinflammatory agents, antiallergens | ICI PHARMA (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0466452-A2 | Thioxo heterocycles and their pharmaceutical use | ZENECA LIMITED (GB) | 1992-01-15 | — | — | EP | disclosed |