Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 9/20 | 0.45 |
| ▸ | HTR1A | P08908 | 8/20 | 0.45 |
| ▸ | FKBP5 | Q13451 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739469 | 0.84 | ABCB1 (0.55) | HTR1A | |
| SCHEMBL9208504 | 0.83 | HRH2 (0.49) | LTA4HKDM4EALDH1A1KMT2A | |
| SCHEMBL9212896 | 0.83 | ABCB1 (0.48) | ADRA1AADRA1BLTA4HKDM4EMEN1 | |
| SCHEMBL9741170 | 0.82 | FAAH (0.52) | ADRA1AADRA1BLTA4HDRD3FKBP5 | |
| SCHEMBL9739220 | 0.78 | HRH3 (0.52) | DRD3KDM4EALDH1A1KMT2A | |
| SCHEMBL9208592 | 0.78 | HTR1A (0.50) | HTR1A | |
| SCHEMBL9739552 | 0.78 | CHRNB2 (0.57) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9740303 | 0.77 | HRH3 (0.60) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9738921 | 0.75 | HTR1A (0.48) | HTR1AKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9211609 | 0.74 | KDM4E (0.55) | DRD3HTR7HTR1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |