Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307254 | 0.88 | MMP1 (0.49) | MMP1MMP3MMP9KLK5MAPT | |
| Iodide SCHEMBL9223621 | 0.80 | MAPT (0.43) | MMP1MMP3MMP9KLK5MAPT | |
| Iodide SCHEMBL9223883 | 0.79 | CCKBR (0.43) | MMP1MMP3MMP9KLK5MAPT | |
| SCHEMBL7302254 | 0.79 | TDP1 (0.46) | MMP1MMP3MMP9KLK5MAPT | |
| SCHEMBL7296817 | 0.79 | MAPT (0.44) | MMP1MMP3MMP9KLK5MAPT | |
| Iodide SCHEMBL9221941 | 0.78 | CCKBR (0.43) | MMP1MMP3MMP9KLK5MAPT | |
| SCHEMBL9215215 | 0.78 | ITGB3 (0.52) | MMP1MMP3MMP9MAPTTDP1 | |
| SCHEMBL7301659 | 0.78 | CTSG (0.46) | MAPTTDP1CTSGCMA1PSMB5 | |
| SCHEMBL4941724 | 0.78 | ACE (0.58) | MMP1MMP3MMP9KLK5MAPT | |
| Iodide SCHEMBL9215204 | 0.78 | ITGB3 (0.51) | MMP1MMP3MMP9MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |