Sugi Predict

Sugi Predict / Compounds / SCHEMBL925829

SCHEMBL925829

SCHEMBL925829

CC1CCC(C(C)C)C(C(=O)Nc2ccc3c(c2)OCO3)C1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 3/20 0.61
▸ NPC1 O15118 7/20 0.54
▸ RAB9A P51151 7/20 0.54
▸ LMNA P02545 1/20 0.50
▸ SMN1; SMN2 Q16637 5/20 0.49
▸ MAPT P10636 3/20 0.49
▸ POLB P06746 2/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ TDP1 Q9NUW8 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ TP53 P04637 2/20 0.47
▸ TRPV1 Q8NER1 1/20 0.47
▸ NFKB1 P19838 1/20 0.46
▸ NFKB2 Q00653 1/20 0.46
▸ RELA Q04206 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2628765 1.00 TRPM8 (0.61) TRPM8NPC1RAB9ALMNASMN1; SMN2
SCHEMBL20446971 0.92 NPC1 (0.55) TRPM8NPC1RAB9ALMNASMN1; SMN2
SCHEMBL2628739 0.81 TRPM8 (0.67) TRPM8NPC1RAB9APOLBMEN1
SCHEMBL14565718 0.81 TRPM8 (0.67) TRPM8NPC1RAB9APOLBMEN1
SCHEMBL18105712 0.81 RAB9A (0.54) NPC1RAB9ALMNASMN1; SMN2MAPT
SCHEMBL19072591 0.81 NPC1 (0.67) NPC1RAB9ALMNASMN1; SMN2MAPT
SCHEMBL2628764 0.80 TRPM8 (0.65) TRPM8MEN1KMT2AALDH1A1TRPV1
SCHEMBL2628672 0.79 TRPM8 (0.75) TRPM8NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL4817319 0.79 TRPM8 (0.75) TRPM8NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL10073486 0.79 TRPM8 (0.75) TRPM8NPC1RAB9ASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163006-A1 New Coolants, and Preparations Containing Same SYMRISE AG (DE) 2025-05-22 — — US claimed
US-20250066320-A1 Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same SYMRISE AG (DE) 2025-02-27 — — US claimed
EP-4469439-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2024-12-04 — — EP claimed
CN-118984825-A Novel cooling agent and preparation containing same 西姆莱斯股份公司 2024-11-19 — — CN claimed
EP-4452941-A1 ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2024-10-30 — — EP claimed
US-20240058259-A1 COMPOSITIONS COMPRISING ESSENTIAL OILS FIRMENICH SA (CH) 2024-02-22 — — US claimed
US-20240000746-A1 New Cooling Agents and Preparations Containing Them SYMRISE AG (DE) 2024-01-04 — — US claimed
EP-3494104-B1 WARMING SENSATION COMPOUNDS TAKASAGO PERFUMERY CO LTD (JP) 2023-11-15 — — EP claimed
EP-4247791-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2023-09-27 — — EP claimed
WO-2023144326-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-08-03 — — WO claimed
WO-2023143741-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-08-03 — — WO claimed
WO-2023117119-A1 ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-06-29 — — WO claimed
WO-2022105986-A1 NOVEL COOLING AGENTS AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 — — WO claimed
WO-2022106452-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 — — WO claimed
EP-3996506-A1 FORMULATIONS FOR CONTROL AND REPELLENCY OF BITING ARTHROPODS Bedoukian Research, Inc. (US) 2022-05-18 — — EP claimed
EP-3996505-A1 SYNERGISTIC FORMULATIONS FOR CONTROL AND REPELLENCY OF BITING ARTHROPODS Bedoukian Research, Inc. (US) 2022-05-18 — — EP claimed
CN-109803948-B Warming sensation compound 高砂香料工业株式会社 2022-03-01 — — CN claimed
US-20260101914-A1 VANILLA COMPOSITION FIRMENICH & CIE (CH) 2026-04-16 — — US disclosed
US-7868004-B2 Menthane carboxamide derivatives having cooling properties GIVAUDAN S.A. (CH) 2011-01-11 — — US disclosed
US-20080305051-A1 Menthane Carboxamide Derivatives Having Cooling Properties GIVAUDAN S.A. (CH) 2008-12-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260101914-A1 VANILLA COMPOSITION TAS2R19, TAS2R9, TAS2R39 TRPM8 189/4885NPC1 2888/4885RAB9A 1888/4885
US-20250066320-A1 Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same TAS2R5, TAS2R7, TAS2R8 TRPM8 363/4885NPC1 1554/4885RAB9A 305/4885
US-20240000746-A1 New Cooling Agents and Preparations Containing Them TTPA, TREH, TAS2R45 TRPM8 132/4885NPC1 1001/4885RAB9A 3257/4885
US-20250163006-A1 New Coolants, and Preparations Containing Same TTR, TAS2R5, TAS2R50 TRPM8 152/4885NPC1 2722/4885RAB9A 2667/4885
US-20080305051-A1 Menthane Carboxamide Derivatives Having Cooling Properties MDH2, ME2, H1-0 TRPM8 72/4885NPC1 4322/4885RAB9A 2348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.