Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 4/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | MASP2 | O00187 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9254764 | 0.83 | EPHX1 (0.38) | SMN1; SMN2MAPK1L3MBTL1GLSRAB9A | |
| SCHEMBL9250720 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPK1L3MBTL1GLSCSNK2A2 | |
| SCHEMBL9247290 | 0.81 | TMPRSS15 (0.35) | CSNK2A2CSNK2A1RAB9ANPC1HDAC6 | |
| SCHEMBL9257782 | 0.79 | CSNK2A2 (0.39) | SMN1; SMN2GLSCSNK2A2CSNK2A1RAB9A | |
| SCHEMBL9568201 | 0.79 | MAPT (0.39) | SMN1; SMN2RAB9AHPGDMEN1KMT2A | |
| SCHEMBL9255100 | 0.77 | KDM4E (0.36) | SMN1; SMN2MAPK1L3MBTL1HDAC6KDM4E | |
| SCHEMBL9254355 | 0.76 | PDK1 (0.35) | NPC1CASP1MASP2 | |
| SCHEMBL7389689 | 0.74 | L3MBTL1 (0.37) | SMN1; SMN2L3MBTL1RAB9ANPC1KDM4E | |
| SCHEMBL9568146 | 0.73 | YAP1 (0.43) | SMN1; SMN2HDAC6KMT2AMASP2LMNA | |
| SCHEMBL8407251 | 0.71 | SRD5A2 (0.48) | SMN1; SMN2KMT2AMASP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463071-A | Tetrazole derivatives; useful for inhibiting undesirable cell aggregation | DR. KARL THOMAE GMBH (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0525629-A2 | 5-membered heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |