Sugi Predict

Sugi Predict / Compounds / SCHEMBL92710

SCHEMBL92710

SCHEMBL92710

C[C@H](N)C(=O)c1[c]nc2ccccc2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 1/20 0.43
▸ IKBKB O14920 1/20 0.36
▸ TLR8 Q9NR97 2/20 0.35
▸ MGAM O43451 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ ALDH1A1 P00352 4/20 0.33
▸ HPGD P15428 3/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ PRNP P04156 2/20 0.33
▸ NPSR1 Q6W5P4 2/20 0.33
▸ RXFP1 Q9HBX9 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ GLA P06280 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ ACHE P22303 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ STAT3 P40763 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5749007 0.79 IKBKB (0.49) IKBKBMGAMALDH1A1HPGDKDM4E
SCHEMBL9022523 0.77 MGAM (0.47) IKBKBMGAMCYP1A2ALDH1A1HPGD
SCHEMBL4923644 0.75 ALOX15 (0.44) ALDH1A1HPGDKDM4EKMT2ANPSR1
SCHEMBL4915820 0.72 CYP1A2 (0.45) CYP1A2ALDH1A1HPGDKDM4EKMT2A
SCHEMBL530809 0.71 MGAM (0.61) ELANEMGAMCYP1A2KDM4EKMT2A
SCHEMBL9658680 0.68 ELANE (0.37) ELANECYP1A2ALDH1A1KDM4ERAB9A
SCHEMBL9658676 0.68 ELANE (0.37) ELANECYP1A2ALDH1A1KDM4ERAB9A
SCHEMBL4966229 0.68 ALDH1A1 (0.38) TLR8MGAMCYP1A2ALDH1A1HPGD
SCHEMBL521935 0.65 NQO2 (0.46) TLR8CYP1A2ALDH1A1HPGDKDM4E
SCHEMBL269884 0.65 ALDH1A1 (0.46) IKBKBMGAMCYP1A2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2697246-B1 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF GENESIS TECH LIMITED (BB) 2018-03-07 — — EP claimed
EP-2288615-B1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF GENESIS TECH LTD (BB) 2017-06-21 — — EP claimed
US-9562069-B2 Selective caspase inhibitors and uses thereof NEW WORLD LABORATORIES INC. (CA) 2017-02-07 — — US claimed
US-20150011458-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF NEW WORLD LABORATORIES INC. (CA) 2015-01-08 — — US claimed
US-8791235-B2 Selective caspase inhibitors and uses thereof NOVAGENESIS FOUNDATION (CH) 2014-07-29 — — US claimed
EP-2697246-A1 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF Novagenesis Foundation (CH) 2014-02-19 — — EP claimed
US-20140038903-A1 Selective Cysteine Protease Inhibitors and Uses Thereof NEW WORLD LABORATORIES, INC. (CA) 2014-02-06 — — US claimed
WO-2012140500-A9 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF NEW WORLD LABORATORIES, INC. (CA) 2013-10-24 — — WO claimed
WO-2012140500-A1 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF NEW WORLD LABORATORIES, INC. (CA) 2012-10-18 — — WO claimed
JP-2011524340-A — — 2011-09-01 — — JP claimed
US-20110077190-A1 Selective Caspase Inhibitors and Uses Thereof GENESIS TECHNOLOGIES LIMITED (BB) 2011-03-31 — — US claimed
EP-2288615-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF New World Laboratories Inc. (CA) 2011-03-02 — — EP claimed
WO-2009140765-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF NEW WORLD LABORATORIES INC. (CA) 2009-11-26 — — WO claimed
US-10975119-B2 Selective cysteine protease inhibitors and uses thereof GENESIS TECHNOLOGIES LIMITED (BB) 2021-04-13 — — US disclosed
US-10167313-B2 Selective caspase inhibitors and uses thereof GENESIS TECHNOLOGIES LIMITED (BB) 2019-01-01 — — US disclosed
US-20180186833-A1 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF GENESIS TECH LIMITED (BB) 2018-07-05 — — US disclosed
US-20110077190-A1 Selective Caspase Inhibitors and Uses Thereof GENESIS TECHNOLOGIES LIMITED (BB) 2011-03-31 — — US disclosed
EP-2288615-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF New World Laboratories Inc. (CA) 2011-03-02 — — EP disclosed
WO-2010133000-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF NEW WORLD LABORATORIES INC. (CA) 2010-11-25 — — WO disclosed
WO-2009140765-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF NEW WORLD LABORATORIES INC. (CA) 2009-11-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110077190-A1 Selective Caspase Inhibitors and Uses Thereof CASP3, CASP1, HTRA2 ELANE 138/4885IKBKB 140/4885TLR8 2073/4885
US-20150011458-A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF CASP3, CASP1, HTRA2 ELANE 138/4885IKBKB 140/4885TLR8 2073/4885
US-10167313-B2 Selective caspase inhibitors and uses thereof CASP1, CASP3, CASP5 ELANE 145/4885IKBKB 184/4885TLR8 2110/4885
US-20140038903-A1 Selective Cysteine Protease Inhibitors and Uses Thereof SERPINB1, SERPINE1, CASP5 ELANE 191/4885IKBKB 1505/4885TLR8 4065/4885
US-20180186833-A1 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF SERPINB1, SERPINE1, CASP5 ELANE 191/4885IKBKB 1505/4885TLR8 4065/4885
US-10975119-B2 Selective cysteine protease inhibitors and uses thereof SERPINB1, SERPINE1, CASP5 ELANE 204/4885IKBKB 1522/4885TLR8 4115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.