Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GALR2 | O43603 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14278792 | 0.86 | ALDH1A1 (0.46) | GPR35ALDH1A1KDM4EMAOAHSD17B10 | |
| SCHEMBL1366199 | 0.78 | GPR35 (0.82) | GPR35ALDH1A1MAOAHPGDMAOB | |
| SCHEMBL28582317 | 0.76 | GPR35 (1.00) | GPR35MAOAHSD17B10HPGDMAOB | |
| SCHEMBL21200040 | 0.73 | ERN1 (0.50) | GPR35ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL7874830 | 0.72 | CA12 (0.67) | ALDH1A1KDM4EMAOAHSD17B10HPGD | |
| SCHEMBL7881409 | 0.72 | MAOA (0.51) | ALDH1A1KDM4EMAOAHSD17B10HPGD | |
| SCHEMBL5902062 | 0.72 | GAA (0.50) | GPR35ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL1983840 | 0.72 | GPR35 (0.68) | GPR35 | |
| SCHEMBL28575714 | 0.71 | GPR35 (1.00) | GPR35ALDH1A1HPGDCYP1A2MAPT | |
| SCHEMBL978546 | 0.71 | MAPT (0.64) | ALDH1A1KDM4ELMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | disclosed |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | disclosed |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | disclosed |
| EP-1732558-B1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]- PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-29 | — | — | EP | disclosed |
| EP-1781292-B1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-22 | — | — | EP | disclosed |
| EP-1781292-B1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-22 | — | — | EP | disclosed |
| US-7776860-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| EP-1732557-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF MOVEMENT DISORDERS | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | disclosed |
| EP-1732558-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]- PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006005760-A1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-01-19 | — | — | WO | disclosed |
| US-20060013874-A1 | Extended release formulation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one | SOLVAY PHARMACEUTICALS B.V. | 2006-01-19 | — | — | US | disclosed |
| WO-2005092340-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005092339-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF MOVEMENT DISORDERS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005092338-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL) -2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| US-20050215567-A1 | 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
| US-20050215551-A1 | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215551-A1 | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders | HTR1A, HTR1D, HTR1E | GPR35 68/4885ALDH1A1 279/4885KDM4E 2963/4885 |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | HTR1D, HTR1A, HTR1E | GPR35 107/4885ALDH1A1 347/4885KDM4E 2865/4885 |
| US-20050215567-A1 | 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain | HTR1D, HTR1A, HTR5A | GPR35 74/4885ALDH1A1 320/4885KDM4E 3193/4885 |
| US-20060013874-A1 | Extended release formulation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one | SLC18A1, SLC18A2, SLC6A1 | GPR35 680/4885ALDH1A1 378/4885KDM4E 2650/4885 |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | HTR1D, HTR1A, HTR1E | GPR35 107/4885ALDH1A1 347/4885KDM4E 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.