Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 2/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28562770 | 0.94 | MEN1 (0.47) | TP53TSHRPLA2G4BTDP1RARB | |
| SCHEMBL19346642 | 0.87 | LDHA (0.39) | LMNAGAATSHRLDHAPOLB | |
| SCHEMBL13946439 | 0.87 | KMT2A (0.38) | LMNAGAALDHATHRATHRB | |
| SCHEMBL4549708 | 0.85 | MAOA (0.39) | LMNAGAATSHRLDHATDP1 | |
| SCHEMBL19346633 | 0.85 | MEN1 (0.36) | LMNAGAATSHRLDHAPOLB | |
| SCHEMBL10271760 | 0.84 | LMNA (0.40) | LMNAGAATSHRLDHATDP1 | |
| SCHEMBL17934208 | 0.84 | LDHA (0.37) | LMNAGAATP53TSHRLDHA | |
| SCHEMBL19346634 | 0.82 | MEN1 (0.36) | LMNAGAATSHRLDHAPOLB | |
| SCHEMBL17831467 | 0.81 | MEN1 (0.38) | LMNAGAATSHRLDHAPOLB | |
| SCHEMBL29142515 | 0.80 | MAOA (0.43) | LMNATP53TSHRPLA2G4BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362252-A1 | Spirocyclic Heterocycle Compounds Useful as HIV Integrase Inhibitors | MERCK SHARP & DOHME LLC | 2017-12-21 | — | — | US | disclosed |
| US-20170349587-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO., LTD. (JP) | 2017-12-07 | — | — | US | disclosed |
| US-20170334924-A1 | Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9815835-B2 | Substituted polycyclic carbamolypyridone derivative | SHIONOGI & CO., LTD. (JP) | 2017-11-14 | — | — | US | disclosed |
| US-9802959-B2 | Method of producing (4R,12aS)-7,9-dihalo-4-methyl-3,4,12,12a-tetrahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-6,8-diones | SHIONOGI & CO., LTD. (JP) | 2017-10-31 | — | — | US | disclosed |
| EP-2370419-B1 | MALTOL ETHER PROCESSES AND INTERMEDIATES | SHIONOGI & CO (JP) | 2017-09-27 | — | — | EP | disclosed |
| US-20170267693-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2017-09-21 | — | — | US | disclosed |
| US-20170260203-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2017-09-14 | — | — | US | disclosed |
| WO-2017153919-A1 | TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2017-09-14 | — | — | WO | disclosed |
| EP-2376080-B1 | SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES | SHIONOGI & CO (JP) | 2017-09-13 | — | — | EP | disclosed |
| WO-2010011814-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011812-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011815-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| US-20090318421-A1 | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity | VIIV HEALTHCARE COMPANY | 2009-12-24 | — | — | US | disclosed |
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2009-11-19 | — | — | US | disclosed |
| US-7579486-B2 | Metalloprotein inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2009-08-25 | — | — | US | disclosed |
| US-20080161311-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. | 2008-07-03 | — | — | US | disclosed |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO | 2007-05-24 | — | — | US | disclosed |
| US-7211572-B2 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-05-01 | — | — | US | disclosed |
| WO-2007002109-A2 | MULTIDENTATE PYRONE-DERIVED CHELATORS FOR MEDICINAL IMAGING AND CHELATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | LMNA 3336/4885GAA 156/4885TP53 1206/4885 |
| US-20170260203-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | NR4A1, NCOA4, NR4A2 | LMNA 4751/4885GAA 3623/4885TP53 2396/4885 |
| US-20170362252-A1 | Spirocyclic Heterocycle Compounds Useful as HIV Integrase Inhibitors | CCNI, IDH3B, AKR1C3 | LMNA 1075/4885GAA 2832/4885TP53 2249/4885 |
| US-20170334924-A1 | Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors | CCNY, CDKN1A, RPIA | LMNA 938/4885GAA 2137/4885TP53 1908/4885 |
| US-20080161311-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | DNTT, PNP, NNMT | LMNA 2372/4885GAA 885/4885TP53 1643/4885 |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | LMNA 3336/4885GAA 156/4885TP53 1206/4885 |
| US-20170349587-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | PREP, UNG, DPP4 | LMNA 1238/4885GAA 1254/4885TP53 601/4885 |
| US-20090318421-A1 | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity | NR4A1, NCOA4, NR4A2 | LMNA 4751/4885GAA 3615/4885TP53 2384/4885 |
| US-20170267693-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | NR4A1, NCOA4, NR4A2 | LMNA 4751/4885GAA 3623/4885TP53 2396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.