Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5507767 | 0.99 | KDM4E (0.49) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL2935825 | 0.97 | KDM4E (0.48) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| SCHEMBL9228925 | 0.84 | HTR5A (0.52) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| SCHEMBL9230867 | 0.83 | ADRA2C (0.50) | HTR2AHTR1ANCF1HTR1DHTR1B | |
| SCHEMBL9229724 | 0.83 | HTR6 (0.48) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| SCHEMBL9229904 | 0.83 | ADRB1 (0.51) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9225164 | 0.83 | HTR5A (0.51) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9229290 | 0.82 | ADRB1 (0.50) | HTR5AHTR2AHTR6HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9230510 | 0.82 | ADRA2C (0.49) | HTR2AHTR1ANCF1HTR1DHTR1B | |
| SCHEMBL27476454 | 0.82 | HTR6 (0.47) | HTR5AHTR2AHTR6HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-01-06 | — | — | US | claimed |
| EP-1781292-B1 | EXTENDED RELEASE FORMULATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1BENZOPYRAN-2-ONE | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-09-22 | — | — | EP | claimed |
| US-7776860-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-08-17 | — | — | US | claimed |
| EP-1732557-B1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF MOVEMENT DISORDERS | SOLVAY PHARM BV (NL) | 2009-10-28 | — | — | EP | claimed |
| EP-1732556-B1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | SOLVAY PHARM BV (NL) | 2008-03-12 | — | — | EP | claimed |
| EP-1732558-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]- PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | claimed |
| EP-1732557-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF MOVEMENT DISORDERS | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | claimed |
| EP-1732556-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | Solvay Pharmaceuticals B.V. (NL) | 2006-12-20 | — | — | EP | claimed |
| US-20060013874-A1 | Extended release formulation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one | SOLVAY PHARMACEUTICALS B.V. | 2006-01-19 | — | — | US | claimed |
| WO-2005092340-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF PAIN | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | claimed |
| WO-2005092339-A1 | 1-[2H-1-BENZOPYRAN-2-ONE-8-YL]-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF MOVEMENT DISORDERS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | claimed |
| WO-2005092338-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL) -2H-1-BENZOPYRAN-2-ONE AND SALTS AND HYDRATES THEREOF | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-10-06 | — | — | WO | claimed |
| US-20050215567-A1 | 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | claimed |
| US-20050215551-A1 | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | claimed |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. | 2005-09-29 | — | — | US | claimed |
| EP-0969842-A1 | PHARMACEUTICAL COMPOSITION | R.P. Scherer Limited (GB) | 2000-01-12 | — | — | EP | claimed |
| WO-1998042344-A1 | PHARMACEUTICAL COMPOSITION | R. P. SCHERER LIMITED (GB) | 1998-10-01 | — | — | WO | claimed |
| US-8173660-B2 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-05-08 | — | — | US | disclosed |
| CN-1105360-A | 1-[2H-1-benzopyran-2-one-8yl]-piperazin derivative | DUPHAR INT RES (NL) | 1995-07-19 | — | — | CN | disclosed |
| EP-0650964-A1 | 1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215551-A1 | 1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders | HTR1A, HTR1D, HTR1E | HTR5A 4/4885HTR2A 7/4885HTR6 16/4885 |
| US-20050215566-A1 | Process for the preparation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and salts and solvates thereof | HTR1D, HTR1A, HTR1E | HTR5A 4/4885HTR2A 10/4885HTR6 17/4885 |
| US-20050215567-A1 | 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain | HTR1D, HTR1A, HTR5A | HTR5A 3/4885HTR2A 5/4885HTR6 21/4885 |
| US-20060013874-A1 | Extended release formulation of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one | SLC18A1, SLC18A2, SLC6A1 | HTR5A 17/4885HTR2A 18/4885HTR6 26/4885 |
| US-20110003830-A1 | PROCESS FOR THE PREPARATION OF 3-AMINO-8-(1-PIPERAZINYL)-2H-1-BENZOPYRAN-2-ONE AND SALTS AND SOLVATES THEREOF | HTR1D, HTR1A, HTR1E | HTR5A 4/4885HTR2A 10/4885HTR6 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.