Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308680 | 0.83 | ALOX5 (0.52) | ALOX5PRKDCCYP2D6 | |
| SCHEMBL9309282 | 0.79 | ALOX5 (0.48) | ALOX5PRKDCCYP2D6 | |
| SCHEMBL16032104 | 0.72 | CYP2D6 (0.41) | CYP2D6 | |
| SCHEMBL9187324 | 0.71 | RAB9A (0.52) | ALOX5RAB9A | |
| SCHEMBL9310099 | 0.71 | ALOX5 (0.48) | ALOX5PRKDC | |
| SCHEMBL16151158 | 0.70 | CYP2D6 (0.45) | CYP2D6 | |
| SCHEMBL13097002 | 0.69 | MAOB (0.47) | CYP2D6 | |
| SCHEMBL9308093 | 0.69 | MRGPRX4 (0.51) | ALOX5 | |
| SCHEMBL9308170 | 0.68 | ALOX5 (0.52) | ALOX5PRKDC | |
| SCHEMBL9308523 | 0.68 | ALOX5 (0.62) | ALOX5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354865-A | Enzyme inhibitor and inhibiting the leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994005281-A1 | PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1994-03-17 | — | — | WO | disclosed |