Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25246650 | 0.82 | DRD2 (0.46) | ACHE | |
| SCHEMBL6075980 | 0.78 | DRD2 (0.58) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL10640414 | 0.76 | SIGMAR1 (0.52) | LMNAPOLBSIGMAR1MC4RACHE | |
| SCHEMBL11405505 | 0.76 | KDM4E (0.56) | ALDH1A1POLBSIGMAR1MEN1KMT2A | |
| SCHEMBL9311038 | 0.76 | ACHE (0.48) | ALDH1A1LMNAPOLBACHE | |
| SCHEMBL13490646 | 0.75 | LMNA (0.41) | ALDH1A1LMNAPOLBSIGMAR1MC4R | |
| SCHEMBL2904840 | 0.75 | SIGMAR1 (0.53) | LMNAPOLBSIGMAR1MC4RACHE | |
| SCHEMBL11234603 | 0.74 | HTR6 (0.46) | SIGMAR1 | |
| SCHEMBL11220044 | 0.74 | DRD2 (0.57) | ALDH1A1MEN1KMT2AACHE | |
| SCHEMBL31530785 | 0.74 | HTR1A (0.66) | ALDH1A1LMNAKMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |