Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 2/20 | 0.57 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.37 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326797 | 0.86 | ASAH1 (0.44) | ASAH1FAAHEPHX2TRPV1ALDH1A1 | |
| SCHEMBL9326362 | 0.84 | ASAH1 (0.41) | ASAH1FAAHEPHX2TRPV1 | |
| SCHEMBL9327916 | 0.79 | MAPT (0.47) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9325277 | 0.78 | EPHX2 (0.53) | FAAHEPHX2TRPV1ALDH1A1 | |
| SCHEMBL8335749 | 0.73 | ASAH1 (1.00) | ASAH1FAAHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9839348 | 0.71 | HPGD (0.53) | FAAHTRPV1MEN1KMT2A | |
| SCHEMBL8776663 | 0.71 | ASAH1 (0.87) | ASAH1FAAHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9160196 | 0.71 | FAAH (0.35) | FAAHALDH1A1 | |
| SCHEMBL8985104 | 0.70 | LMNA (0.36) | ALDH1A1 | |
| SCHEMBL9744651 | 0.70 | ALDH1A1 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5212172-A | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-5081147-A | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-14 | — | — | US | disclosed |