Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 4/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985108 | 0.95 | PPARA (0.33) | LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL9128899 | 0.80 | LMNA (0.38) | LMNAMAPTMAPK1ELANEALDH1A1 | |
| SCHEMBL9326362 | 0.78 | ASAH1 (0.41) | LMNAMAPTMAPK1ELANE | |
| SCHEMBL9736017 | 0.78 | MAPT (0.47) | LMNAMAPTELANEALDH1A1PRKCA | |
| SCHEMBL9327916 | 0.78 | MAPT (0.47) | LMNAMAPTELANEALDH1A1PRKCA | |
| SCHEMBL9326199 | 0.77 | PRKCA (0.46) | LMNAMAPTELANEALDH1A1PRKCA | |
| SCHEMBL8985142 | 0.77 | FFAR4 (0.36) | LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL9744651 | 0.75 | ALDH1A1 (0.32) | MAPTELANEALDH1A1 | |
| SCHEMBL8985096 | 0.75 | SIGMAR1 (0.34) | LMNAALDH1A1 | |
| SCHEMBL9159891 | 0.74 | FAAH (0.35) | MAPTELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541221-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0637240-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS | ALLERGAN, INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5387606-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5268387-A | Containing ester or carbamate group | ALLERGAN, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1993021915-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES | ALLERGAN, INC. (US) | 1993-11-11 | — | — | WO | disclosed |
| US-5171864-A | Immunosuppressant, anti-proliferative activity | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |