Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.33 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.33 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL670699 | 0.78 | — | — | |
| SCHEMBL13537856 | 0.69 | ALDH1A1 (0.43) | MMP8METAP2METAP1ALDH1A1 | |
| SCHEMBL803891 | 0.69 | ALDH1A1 (0.43) | MMP8METAP2METAP1ALDH1A1 | |
| SCHEMBL803804 | 0.69 | ALDH1A1 (0.43) | MMP8METAP2METAP1ALDH1A1 | |
| Sulfuric Acid SCHEMBL9420942 | 0.69 | ALDH1A1 (0.39) | CA12CA1CA2CA9METAP2 | |
| Trifluoromethanesulfonic Acid SCHEMBL27373538 | 0.68 | POLB (0.38) | CA12CA1CA2CA9POLB | |
| SCHEMBL13070248 | 0.68 | ALDH1A1 (0.42) | MMP8METAP2METAP1ALDH1A1 | |
| SCHEMBL20569154 | 0.68 | ALDH1A1 (0.42) | MMP8METAP2METAP1ALDH1A1 | |
| SCHEMBL16377922 | 0.67 | ALDH1A1 (0.37) | CA12CA1CA2CA9POLB | |
| SCHEMBL8313137 | 0.66 | MGAM (0.42) | CA12CA1CA2CA9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431112-B1 | HIGH STRENGTH STRUCTURAL PERLITE CONCRETE | ADVANCED CONCRETE TECH (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5114617-A | Cement, pozzolan, fine and coarse aggregates; bonding strength | ADVANCED CONCRETE TECHNOLOGY, INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0431112-A4 | HIGH STRENGTH STRUCTURAL PERLITE CONCRETE | — | 1991-11-27 | — | — | EP | disclosed |
| EP-0431112-A1 | HIGH STRENGTH STRUCTURAL PERLITE CONCRETE. | ADVANCED CONCRETE TECH (US) | 1991-06-12 | — | — | EP | disclosed |
| WO-1990014319-A1 | HIGH STRENGTH STRUCTURAL PERLITE CONCRETE | ADVANCED CONCRETE TECHNOLOGY, INC. (US) | 1990-11-29 | — | — | WO | disclosed |
| US-4801635-A | MIXTURE OF ANIONIC AND NONIONIC POLYMERS AND SURFACTANTS | ZINKAN ENTERPRISES, INC. (US) | 1989-01-31 | — | — | US | disclosed |