Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621020 | 0.88 | CYP2D6 (0.31) | — | |
| SCHEMBL27514652 | 0.68 | HDAC3 (0.43) | ELANECA1FFAR3HDAC3HDAC1 | |
| SCHEMBL2353376 | 0.65 | CA1 (0.43) | ELANECA1FFAR3HDAC3HDAC1 | |
| SCHEMBL27801920 | 0.65 | HDAC3 (0.46) | ELANECA1FFAR3HDAC3HDAC1 | |
| Succinic Acid SCHEMBL24440 | 0.64 | HDAC3 (0.62) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Succinic Acid SCHEMBL3012461 | 0.64 | HDAC3 (0.62) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL30622578 | 0.62 | FFAR3 (0.42) | ELANECA1FFAR3HDAC3HDAC1 | |
| SCHEMBL16722616 | 0.62 | FFAR3 (0.42) | ELANECA1FFAR3HDAC3HDAC1 | |
| SCHEMBL15776451 | 0.62 | HDAC3 (0.42) | ELANECA1FFAR3HDAC3HDAC1 | |
| Succinic Acid SCHEMBL6249858 | 0.62 | TSHR (0.68) | CA1FFAR3HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359442-B1 | Mono-iodopropargyl esters of dicarboxylic anhydrides and their use as antimicrobial agents | LONZA AG (US) | 1994-10-19 | — | — | EP | disclosed |
| US-5073570-A | MONO-IODOPROPARGYL ESTERS OF DICARBOXYLIC ANHYDRIDES AND THEIR USE AS ANTIMICROBIAL AGENTS | LONZA INC. (US) | 1991-12-17 | — | — | US | disclosed |
| EP-0359442-A2 | Mono-iodopropargyl esters of dicarboxylic anhydrides and their use as antimicrobial agents | LONZA INC. (US) | 1990-03-21 | — | — | EP | disclosed |